9SXM

Crystal structure of ERK2 in complex with a ligand

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Mitogen-activated protein kinase 1	polymer	364	42311.7	1	UniProt (P63086) Pfam (PF00069)	Rattus norvegicus (Norway rat)	MAP kinase 1,MAPK 1,ERT1,Extracellular signal-regulated kinase 2,ERK-2,MAP kinase isoform p42,p42-MAPK,Mitogen-activated protein kinase 2,MAP kinase 2,MAPK 2
2	B, C (A)	DIMETHYL SULFOXIDE	non-polymer		78.1	2	Chemie (DMS) PubChem (679)
3	D (A)	SULFATE ION	non-polymer		96.1	1	Chemie (SO4)
4	E (A)	~{N}-[3-[5-[3-(3-oxidanylpropyl)phenyl]-1~{H}-pyrrolo[2,3-b]pyridin-3-yl]-1~{H}-pyrazol-5-yl]ethanamide	non-polymer		375.4	1	Chemie (A1JRQ)
5	F (A)	water	water		18.0	226	Chemie (HOH)

Sequence modifications

A: 1 - 358 (UniProt: P63086)

PDB	External Database	Details
His -5	-	expression tag
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	42311.7
Non-Polymers*	Number of molecules	4
	Total formula weight	627.8
All*	Total formula weight	42939.4

*Water molecules are not included.