9SVN
Structure of dihydrofolate reductase from Burkholderia thailandensis (I99L variant) complexed with trimethoprim and dihydrofolate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Dihydrofolate reductase | polymer | 169 | 18489.9 | 5 | UniProt (A0AAW9D207) | Burkholderia thailandensis | |
| 2 | F, J, M, S, V (A, B, C, D, E) | TRIMETHOPRIM | non-polymer | 290.3 | 5 | Chemie (TOP) PubChem (5578) | |||
| 3 | G, K, N, T, W (A, B, C, D, E) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 5 | Chemie (NDP) | |||
| 4 | H, I, L, O, P... (A, B, C, D, E) | SULFATE ION | non-polymer | 96.1 | 11 | Chemie (SO4) | |||
| 5 | AA, BA, CA, DA, EA (A, B, C, D, E) | water | water | 18.0 | 291 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 167 (UniProt: A0AAW9D207)
| PDB | External Database | Details |
|---|---|---|
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| Leu 99 | Ile 99 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 92449.7 | |
| Non-Polymers* | Number of molecules | 21 |
| Total formula weight | 6235.4 | |
| All* | Total formula weight | 98685.1 |
