9SV0
Crystal structure of Aurora-A bound to DBS4
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | DBS4 | polymer | 70 | 7657.7 | 2 | synthetic construct | ||
| 2 | B, D (B, D) | Aurora kinase A | polymer | 285 | 32899.7 | 2 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (human) | Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,Breast tumor-amplified kinase,Ipl1- and aurora-related kinase 1,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase Ayk1,Serine/threonine-protein kinase aurora-A |
| 3 | E, I (B, D) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 4 | F, G (B) | 3[N-MORPHOLINO]PROPANE SULFONIC ACID | non-polymer | 209.3 | 2 | Chemie (MPO) PubChem (70807) | |||
| 5 | H, K (B, D) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | J (D) | PHOSPHATE ION | non-polymer | 95.0 | 1 | Chemie (PO4) PubChem (1061) | |||
| 7 | L, M, N, O (A, B, C, D) | water | water | 18.0 | 237 | Chemie (HOH) |
Sequence modifications
B, D: 122 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 119 | - | expression tag |
| Ser 120 | - | expression tag |
| Met 121 | - | expression tag |
| Asn 274 | Asp 274 | engineered mutation |
| Ala 290 | Cys 290 | engineered mutation |
| Ala 393 | Cys 393 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 81114.8 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 1416.5 | |
| All* | Total formula weight | 82531.3 |
