9SUM
CryoEM structure of Candida auris 80S ribosome in complex with Cycloheximide and Geneticin G418
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (1) | P-site tRNA | polymer | 76 | 24445.5 | 1 | Candidozyma auris | ||
| 2 | B (2) | RNA (5'-R(P*CP*GP*A)-3') | polymer | 3 | 934.6 | 1 | Candidozyma auris | ||
| 3 | C (A) | 25S rRNA | polymer | 3283 | 1061233.5 | 1 | Candidozyma auris | ||
| 4 | D (B) | 5S rRNA | polymer | 122 | 39392.4 | 1 | Candidozyma auris | ||
| 5 | E (C) | 5.8S rRNA | polymer | 158 | 50697.9 | 1 | Candidozyma auris | ||
| 6 | F (CA) | 18S rRNA | polymer | 1775 | 572453.5 | 1 | Candidozyma auris | ||
| 7 | G (D) | 60S ribosomal protein L2-A | polymer | 254 | 27418.6 | 1 | UniProt (A0A2H0ZK83) | Candidozyma auris | |
| 8 | H (E) | Large ribosomal subunit protein uL3 | polymer | 389 | 44056.8 | 1 | UniProt (A0A2H0ZM86) | Candidozyma auris | 60S ribosomal protein L3 |
| 9 | I (F) | 60S ribosomal protein L4-A | polymer | 363 | 39776.9 | 1 | UniProt (A0A2H0ZM70) | Candidozyma auris | |
| 10 | J (G) | 60S ribosomal protein L5 | polymer | 298 | 34402.0 | 1 | UniProt (A0A2H0ZCP9) | Candidozyma auris | |
| 11 | K (H) | 60S ribosomal protein L6 | polymer | 165 | 18547.7 | 1 | UniProt (A0A2H0ZD81) | Candidozyma auris | |
| 12 | L (I) | 60S ribosomal protein L7 | polymer | 241 | 27510.0 | 1 | UniProt (A0A2H0ZFX1) | Candidozyma auris | |
| 13 | M (J) | 60S ribosomal protein L8 | polymer | 263 | 29143.4 | 1 | UniProt (A0A2H0ZJ33) | Candidozyma auris | |
| 14 | N (K) | 60S ribosomal protein L9-B | polymer | 191 | 21692.2 | 1 | UniProt (A0A2H0ZVC9) | Candidozyma auris | |
| 15 | O (L) | 60S ribosomal protein L10 | polymer | 220 | 25397.5 | 1 | UniProt (A0A0L0NQG7) | Candidozyma auris | |
| 16 | P (M) | 60S ribosomal protein L11-A | polymer | 172 | 19645.7 | 1 | UniProt (A0A2H1A6W9) | Candidozyma auris | |
| 17 | Q (N) | 60S ribosomal protein L13 | polymer | 198 | 22364.0 | 1 | UniProt (A0A8F2VY16) | Candidozyma auris | |
| 18 | R (O) | Large ribosomal subunit protein eL14 domain-containing protein | polymer | 131 | 14841.5 | 1 | UniProt (A0A2H0ZKB9) | Candidozyma auris | |
| 19 | S (P) | Ribosomal protein L15 | polymer | 204 | 24249.0 | 1 | UniProt (A0A2H0ZYM3) | Candidozyma auris | |
| 20 | T (Q) | 60S ribosomal protein L16-B | polymer | 200 | 22637.8 | 1 | UniProt (A0A2H1A1L1) | Candidozyma auris | |
| 21 | U (R) | 60S ribosomal protein L17-B | polymer | 185 | 20999.0 | 1 | UniProt (A0A2H0ZLP7) | Candidozyma auris | |
| 22 | V (S) | 60S ribosomal protein L18-A | polymer | 186 | 20793.5 | 1 | UniProt (A0A2H1A3M0) | Candidozyma auris | |
| 23 | W (T) | Ribosomal protein L19 | polymer | 208 | 24042.4 | 1 | UniProt (A0A2H0ZNX4) | Candidozyma auris | |
| 24 | X (U) | 60S ribosomal protein L20-A | polymer | 186 | 22128.9 | 1 | Candidozyma auris | ||
| 25 | Y (V) | 60S ribosomal protein L21-A | polymer | 160 | 18343.5 | 1 | Candidozyma auris | ||
| 26 | Z (W) | 60S ribosomal protein L22 | polymer | 119 | 13684.5 | 1 | UniProt (A0A2H0ZQD9) | Candidozyma auris | |
| 27 | AA (X) | 60S ribosomal protein L23-B | polymer | 137 | 14529.0 | 1 | UniProt (A0A2H1A034) | Candidozyma auris | |
| 28 | BA (Y) | 60S ribosomal protein L24 | polymer | 156 | 18011.9 | 1 | UniProt (A0A5C1DRN4) | Candidozyma auris | |
| 29 | CA (Z) | Large ribosomal subunit protein uL23 | polymer | 140 | 15537.1 | 1 | UniProt (A0A2H1A599) | Candidozyma auris | 60S ribosomal protein L25 |
| 30 | DA (ZA) | 40S ribosomal protein S8 | polymer | 204 | 23192.6 | 1 | UniProt (A0A2H0ZM29) | Candidozyma auris | |
| 31 | EA (ZB) | 40S ribosomal protein S9-A | polymer | 189 | 21933.3 | 1 | UniProt (A0A2H1A2S6) | Candidozyma auris | |
| 32 | FA (ZC) | 40S ribosomal protein S10-A | polymer | 123 | 14494.6 | 1 | UniProt (A0A2H0ZTM6) | Candidozyma auris | |
| 33 | GA (ZD) | 40S ribosomal protein S11-A | polymer | 155 | 17769.9 | 1 | UniProt (A0A2H0ZRL1) | Candidozyma auris | |
| 34 | HA (ZE) | 40S ribosomal protein S13 | polymer | 151 | 17045.9 | 1 | UniProt (A0A2H0ZYS2) | Candidozyma auris | |
| 35 | IA (ZF) | Small ribosomal subunit protein uS11 | polymer | 132 | 14068.1 | 1 | UniProt (A0A8F2W0L8) | Candidozyma auris | |
| 36 | JA (ZG) | 40S ribosomal protein S15 | polymer | 141 | 15802.5 | 1 | UniProt (A0A2H0ZND6) | Candidozyma auris | |
| 37 | KA (ZH) | Small ribosomal subunit protein uS9 | polymer | 142 | 15738.4 | 1 | UniProt (A0A2H0ZSF0) | Candidozyma auris | |
| 38 | LA (ZI) | 40S ribosomal protein S17-B | polymer | 137 | 15787.3 | 1 | UniProt (A0A2H1A7E5) | Candidozyma auris | |
| 39 | MA (ZJ) | 40S ribosomal protein S18 | polymer | 145 | 17042.8 | 1 | UniProt (A0A8F3AFG8) | Candidozyma auris | |
| 40 | NA (ZK) | 40S ribosomal protein S19-A | polymer | 145 | 16094.2 | 1 | UniProt (A0A2H1A3R4) | Candidozyma auris | |
| 41 | OA (ZL) | Small ribosomal subunit protein uS10 | polymer | 118 | 13130.4 | 1 | UniProt (A0A5Q7YDP5) | Candidozyma auris | 40S ribosomal protein S20 |
| 42 | PA (ZM) | 40S ribosomal protein S21 | polymer | 87 | 9676.8 | 1 | UniProt (A0A2H1A6K7) | Candidozyma auris | |
| 43 | QA (ZO) | 40S ribosomal protein S22 | polymer | 130 | 14811.2 | 1 | UniProt (A0A2H0ZHF9) | Candidozyma auris | |
| 44 | RA (ZP) | 40S ribosomal protein S23 | polymer | 145 | 15987.7 | 1 | UniProt (A0A8F2VYJ1) | Candidozyma auris | |
| 45 | SA (ZQ) | 40S ribosomal protein S24 | polymer | 135 | 15558.0 | 1 | UniProt (A0A2H0ZS48) | Candidozyma auris | |
| 46 | TA (ZR) | 40S ribosomal protein S25 | polymer | 130 | 14507.3 | 1 | UniProt (A0A2H0ZGB6) | Candidozyma auris | |
| 47 | UA (ZS) | 40S ribosomal protein S26 | polymer | 182 | 20505.3 | 1 | UniProt (A0A2H1A734) | Candidozyma auris | |
| 48 | VA (ZT) | 40S ribosomal protein S27 | polymer | 82 | 9027.5 | 1 | UniProt (A0A2H1A3C7) | Candidozyma auris | |
| 49 | WA (ZU) | 40S ribosomal protein S28-A | polymer | 67 | 7582.8 | 1 | UniProt (A0A2H0ZSJ0) | Candidozyma auris | |
| 50 | XA (ZV) | Small ribosomal subunit protein uS14 | polymer | 56 | 6615.6 | 1 | UniProt (A0A1D8PTR4) | Candidozyma auris | 40S ribosomal protein S29A |
| 51 | YA (ZW) | Small ribosomal subunit protein eS30 | polymer | 63 | 7127.4 | 1 | UniProt (A0A1D8PSK2) | Candidozyma auris | 40S ribosomal protein S30 |
| 52 | ZA (ZY) | Small ribosomal subunit protein RACK1 | polymer | 315 | 34479.6 | 1 | UniProt (A0A2H0ZFC0) | Candidozyma auris | Guanine nucleotide-binding protein subunit beta-like protein |
| 53 | AB (a) | Ribosomal protein L24 | polymer | 127 | 14303.8 | 1 | UniProt (A0A2H1A4U4) | Candidozyma auris | |
| 54 | BB (b) | 60S ribosomal protein L27 | polymer | 136 | 15454.1 | 1 | UniProt (A0A2H0ZUP3) | Candidozyma auris | |
| 55 | CB (c) | 60S ribosomal protein L28 | polymer | 149 | 16773.5 | 1 | UniProt (A0A2H1A7N8) | Candidozyma auris | |
| 56 | DB (d) | 60S ribosomal protein L29 | polymer | 76 | 8971.4 | 1 | UniProt (A0A2H0ZCV4) | Candidozyma auris | |
| 57 | EB (e) | 60S ribosomal protein L30 | polymer | 105 | 11281.2 | 1 | UniProt (A0A2H0ZR23) | Candidozyma auris | |
| 58 | FB (f) | 60S ribosomal protein L31-A | polymer | 113 | 13196.3 | 1 | UniProt (A0A2H0ZNZ0) | Candidozyma auris | |
| 59 | GB (g) | 60S ribosomal protein L32 | polymer | 149 | 17071.9 | 1 | UniProt (A0A2H0ZG69) | Candidozyma auris | |
| 60 | HB (h) | 60S ribosomal protein L33-A | polymer | 107 | 12309.3 | 1 | UniProt (A0A5Q7YIA8) | Candidozyma auris | |
| 61 | IB (i) | 60S ribosomal protein L34-B | polymer | 115 | 13101.5 | 1 | UniProt (A0A2H0ZUB3) | Candidozyma auris | |
| 62 | JB (j) | 60S ribosomal protein L35 | polymer | 120 | 13817.5 | 1 | UniProt (A0A2H0ZW26) | Candidozyma auris | |
| 63 | KB (k) | 60S ribosomal protein L36 | polymer | 99 | 11180.2 | 1 | UniProt (A0A2H1A421) | Candidozyma auris | |
| 64 | LB (l) | Ribosomal protein L37 | polymer | 85 | 9616.2 | 1 | UniProt (A0A2H0ZD58) | Candidozyma auris | |
| 65 | MB (m) | Large ribosomal subunit protein eL38 | polymer | 78 | 8916.6 | 1 | UniProt (A0A2H1A739) | Candidozyma auris | 60S ribosomal protein L38 |
| 66 | NB (n) | Large ribosomal subunit protein eL39 | polymer | 51 | 6404.6 | 1 | UniProt (A0A1D8PDT4) | Candidozyma auris | 60S ribosomal protein L39 |
| 67 | OB (o) | Large ribosomal subunit protein eL40 | polymer | 52 | 6078.4 | 1 | UniProt (A0A1D8PL68) | Candidozyma auris | 60S ribosomal protein L40-B |
| 68 | PB (p) | Small ribosomal subunit protein eS32 | polymer | 25 | 3396.3 | 1 | UniProt (P9WER7) | Candidozyma auris | 60S ribosomal protein L41,Large ribosomal subunit protein eL41 |
| 69 | QB (q) | 60S ribosomal protein L44 | polymer | 106 | 12174.5 | 1 | UniProt (A0A2H1A644) | Candidozyma auris | |
| 70 | RB (r) | 60S ribosomal protein L43 | polymer | 99 | 10758.5 | 1 | UniProt (A0A2H0ZK40) | Candidozyma auris | |
| 71 | SB (s) | Small ribosomal subunit protein uS2 | polymer | 264 | 29117.6 | 1 | UniProt (A0A2H0ZDC5) | Candidozyma auris | |
| 72 | TB (t) | Small ribosomal subunit protein eS1 | polymer | 256 | 28866.8 | 1 | UniProt (A0A2H0ZC96) | Candidozyma auris | |
| 73 | UB (u) | Rps21 ribosomal protein | polymer | 249 | 27151.8 | 1 | UniProt (A0AB36VXE5) | Candidozyma auris | |
| 74 | VB (v) | Small ribosomal subunit protein uS3 | polymer | 250 | 27181.6 | 1 | UniProt (A0A2H0ZW29) | Candidozyma auris | 40S ribosomal protein S3 |
| 75 | WB (w) | 40S ribosomal protein S4 | polymer | 264 | 29672.7 | 1 | UniProt (A0A2H0ZMW6) | Candidozyma auris | |
| 76 | XB (x) | 40S ribosomal protein uS7 (formerly S5) | polymer | 223 | 24905.6 | 1 | UniProt (A0AB36W6W7) | Candidozyma auris | |
| 77 | YB (y) | 40S ribosomal protein S6 | polymer | 236 | 27054.2 | 1 | UniProt (A0A2H1A5E3) | Candidozyma auris | |
| 78 | ZB (z) | 40S ribosomal protein eS7 (formerly S7) | polymer | 188 | 21460.0 | 1 | UniProt (A0AB36WC92) | Candidozyma auris | |
| 79 | AC, AJ, AK, AN, BJ... (A, C, CA, E, B...) | GENETICIN | non-polymer | 496.6 | 57 | Chemie (GET) PubChem (123865) | |||
| 80 | AD, AE, AF, AG, AH... (A, CA, k, x, E...) | MAGNESIUM ION | non-polymer | 24.3 | 253 | Chemie (MG) PubChem (888) | |||
| 81 | DN, LI, NI (CA, A) | SPERMIDINE | non-polymer | 145.2 | 3 | Chemie (SPD) PubChem (1102) | |||
| 82 | MI (A) | 4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione | non-polymer | 281.3 | 1 | Chemie (3HE) PubChem (6197) | |||
| 83 | AO, BO, CO, DO, FO... (ZS, ZT, ZV, i, l...) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) PubChem (32051) | |||
| 84 | AP, AQ, BP, BQ, CP... (P, e, Q, f, R...) | water | water | 18.0 | 9959 | Chemie (HOH) |
Sequence modifications
n: 1 - 51 (UniProt: A0A1D8PDT4)
| PDB | External Database | Details |
|---|---|---|
| Asn 50 | Gly 50 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 78 |
| Total formula weight | 3067105.4 | |
| Non-Polymers* | Number of molecules | 322 |
| Total formula weight | 35693.0 | |
| All* | Total formula weight | 3102798.4 |
