9SUK
p53-R282W Core Domain Covalently Bound to a Vinyl-Sulfone Fragment
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cellular tumor antigen p53 | polymer | 219 | 24619.9 | 2 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | C, G, S (A, B) | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID | non-polymer | 238.3 | 3 | Chemie (EPE) PubChem (23831) | |||
| 3 | D, H, L, N (A, B) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 4 | Chemie (PEG) PubChem (8117) | |||
| 4 | E, M (A, B) | 3-bromanyl-1-benzothiophene 1,1-dioxide | non-polymer | 245.1 | 2 | Chemie (A1JQW) | |||
| 5 | F (A) | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) PubChem (753) | |||
| 6 | I, J, O, P, Q... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 6 | Chemie (EDO) | |||
| 7 | K, T (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) PubChem (32051) | |||
| 8 | U, V (A, B) | water | water | 18.0 | 396 | Chemie (HOH) |
Sequence modifications
A, B: 94 - 312 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Leu 133 | Met 133 | variant |
| Ala 203 | Val 203 | variant |
| Tyr 239 | Asn 239 | variant |
| Asp 268 | Asn 268 | engineered mutation |
| Trp 282 | Arg 282 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49239.7 | |
| Non-Polymers* | Number of molecules | 18 |
| Total formula weight | 2224.9 | |
| All* | Total formula weight | 51464.6 |
