9SQX
Crystal structure of IL-17A in complex with compound 19
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | Interleukin-17A | polymer | 123 | 14251.1 | 4 | UniProt (Q16552) Pfam (PF06083) | Homo sapiens (human) | IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8 |
| 2 | E, O (A, D) | ~{N}-[(~{S})-cyclohexyl-[3-[(4-oxidanylidene-3~{H}-phthalazin-1-yl)methyl]-1~{H}-1,2,4-triazol-5-yl]methyl]-4-methyl-1,2,5-oxadiazole-3-carboxamide | non-polymer | 448.5 | 2 | Chemie (A1JPS) | |||
| 3 | F, G, H, I, J... (A, B, C, D) | SULFATE ION | non-polymer | 96.1 | 10 | Chemie (SO4) | |||
| 4 | Q, R, S, T (A, B, C, D) | water | water | 18.0 | 333 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 34 - 155 (UniProt: Q16552)
| PDB | External Database | Details |
|---|---|---|
| Met 33 | - | initiating methionine |
| Ser 129 | Cys 129 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 57004.2 | |
| Non-Polymers* | Number of molecules | 12 |
| Total formula weight | 1857.6 | |
| All* | Total formula weight | 58861.8 |
