9SQN
Structure of a disulfide-bridged complex between HLA-A*02:01-K127N/Y84C and ERp57/tapasin-K16C - State 1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (B) | Beta-2-microglobulin | polymer | 99 | 11750.2 | 1 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 2 | B (D) | Tapasin | polymer | 398 | 42746.5 | 1 | UniProt (O15533) Pfam (PF07654) | Homo sapiens (human) | TPN,TPSN,NGS-17,TAP-associated protein,TAP-binding protein |
| 3 | C (E) | Protein disulfide-isomerase A3 | polymer | 481 | 54309.0 | 1 | UniProt (P30101) Pfam (PF00085) Pfam (PF13848) | Homo sapiens (human) | 58 kDa glucose-regulated protein,58 kDa microsomal protein,p58,Disulfide isomerase ER-60,Endoplasmic reticulum resident protein 57,ER protein 57,ERp57,Endoplasmic reticulum resident protein 60,ER protein 60,ERp60 |
| 4 | D (A) | MHC class I antigen | polymer | 301 | 34291.7 | 1 | UniProt (Q9TQB6) | Homo sapiens (human) | |
| 5 | E (C) | LYS-ILE-LEU-GLY-PHE-VAL-NFA, pKV9 | polymer | 8 | 822.0 | 1 | Homo sapiens | ||
| 6 | F (F) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) |
Sequence modifications
B: 1 - 99 (UniProt: P61769)
D: 1 - 392 (UniProt: O15533)
E: 25 - 505 (UniProt: P30101)
A: 1 - 276 (UniProt: Q9TQB6)
| PDB | External Database | Details |
|---|---|---|
| Cys 4 | Thr 24 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 16 | Lys 36 | engineered mutation |
| Arg 240 | Thr 260 | variant |
| Cys 304 | Gly 324 | engineered mutation |
| His 393 | - | expression tag |
| His 394 | - | expression tag |
| His 395 | - | expression tag |
| His 396 | - | expression tag |
| His 397 | - | expression tag |
| His 398 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala 85 | Cys 85 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Cys 84 | Tyr 108 | engineered mutation |
| Gly 277 | - | expression tag |
| Ser 278 | - | expression tag |
| Gly 279 | - | expression tag |
| Gly 280 | - | expression tag |
| Ser 281 | - | expression tag |
| Gly 282 | - | expression tag |
| Gly 283 | - | expression tag |
| Ser 284 | - | expression tag |
| Ala 285 | - | expression tag |
| Gly 286 | - | expression tag |
| Gly 287 | - | expression tag |
| Gly 288 | - | expression tag |
| Leu 289 | - | expression tag |
| Asn 290 | - | expression tag |
| Asp 291 | - | expression tag |
| Ile 292 | - | expression tag |
| Phe 293 | - | expression tag |
| Glu 294 | - | expression tag |
| Ala 295 | - | expression tag |
| Gln 296 | - | expression tag |
| Lys 297 | - | expression tag |
| Ile 298 | - | expression tag |
| Glu 299 | - | expression tag |
| Trp 300 | - | expression tag |
| His 301 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 143919.5 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 910.8 | |
| All* | Total formula weight | 144830.3 |
