9SMI
Reduced bovine complex I in lipid nanodisc, NADH-deactive
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NADH-ubiquinone oxidoreductase chain 3 | polymer | 115 | 13086.5 | 1 | UniProt (Q7JAS9) | Bos taurus (domestic cattle) | |
| 2 | B (B) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial | polymer | 216 | 23818.9 | 1 | UniProt (P42026) | Bos taurus (domestic cattle) | Complex I-20kD,CI-20kD,NADH-ubiquinone oxidoreductase 20 kDa subunit,PSST subunit |
| 3 | C (C) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial | polymer | 266 | 30323.4 | 1 | UniProt (P23709) | Bos taurus (domestic cattle) | Complex I-30kD,CI-30kD,NADH-ubiquinone oxidoreductase 30 kDa subunit |
| 4 | D (D) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial | polymer | 463 | 52678.5 | 1 | UniProt (P17694) | Bos taurus (domestic cattle) | Complex I-49kD,CI-49kD,NADH-ubiquinone oxidoreductase 49 kDa subunit |
| 5 | E (E) | NADH dehydrogenase [ubiquinone] flavoprotein 2, mitochondrial | polymer | 249 | 27341.5 | 1 | UniProt (P04394) | Bos taurus (domestic cattle) | NADH dehydrogenase subunit II,NADH-ubiquinone oxidoreductase 24 kDa subunit |
| 6 | F (F) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial | polymer | 464 | 50718.8 | 1 | UniProt (P25708) | Bos taurus (domestic cattle) | Complex I-51kD,CI-51kD,NADH dehydrogenase flavoprotein 1,NADH-ubiquinone oxidoreductase 51 kDa subunit |
| 7 | G (G) | NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial | polymer | 727 | 79532.2 | 1 | UniProt (P15690) | Bos taurus (domestic cattle) | Complex I-75kD,CI-75kD |
| 8 | H (H) | NADH-ubiquinone oxidoreductase chain 1 | polymer | 318 | 35716.8 | 1 | UniProt (P03887) | Bos taurus (domestic cattle) | |
| 9 | I (I) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial | polymer | 212 | 23926.4 | 1 | UniProt (P42028) | Bos taurus (domestic cattle) | Complex I-23kD,CI-23kD,NADH-ubiquinone oxidoreductase 23 kDa subunit,TYKY subunit |
| 10 | J (J) | NADH-ubiquinone oxidoreductase chain 6 | polymer | 175 | 19110.5 | 1 | UniProt (P03924) | Bos taurus (domestic cattle) | NADH dehydrogenase subunit 6 |
| 11 | K (K) | NADH-ubiquinone oxidoreductase chain 4L | polymer | 98 | 10828.2 | 1 | UniProt (P03902) | Bos taurus (domestic cattle) | NADH dehydrogenase subunit 4L |
| 12 | L (L) | NADH-ubiquinone oxidoreductase chain 5 | polymer | 606 | 68355.9 | 1 | UniProt (P03920) | Bos taurus (domestic cattle) | NADH dehydrogenase subunit 5 |
| 13 | M (M) | NADH-ubiquinone oxidoreductase chain 4 | polymer | 459 | 52158.8 | 1 | UniProt (P03910) | Bos taurus (domestic cattle) | NADH dehydrogenase subunit 4 |
| 14 | N (N) | NADH-ubiquinone oxidoreductase chain 2 | polymer | 347 | 39302.9 | 1 | UniProt (P03892) | Bos taurus (domestic cattle) | NADH dehydrogenase subunit 2 |
| 15 | O (O) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial | polymer | 343 | 39331.0 | 1 | UniProt (P34942) | Bos taurus (domestic cattle) | Complex I-42kD,CI-42kD,NADH-ubiquinone oxidoreductase 42 kDa subunit |
| 16 | P (P) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial | polymer | 380 | 42913.4 | 1 | UniProt (P34943) | Bos taurus (domestic cattle) | Complex I-39kD,CI-39kD,NADH-ubiquinone oxidoreductase 39 kDa subunit |
| 17 | Q (Q) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial | polymer | 175 | 19841.6 | 1 | UniProt (Q02375) | Bos taurus (domestic cattle) | Complex I-18 kDa,CI-18 kDa,Complex I-AQDQ,CI-AQDQ,NADH-ubiquinone oxidoreductase 18 kDa subunit |
| 18 | R (R) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial | polymer | 124 | 13433.2 | 1 | UniProt (P23934) | Bos taurus (domestic cattle) | Complex I-13kD-A,CI-13kD-A,NADH-ubiquinone oxidoreductase 13 kDa-A subunit |
| 19 | S (S) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 2 | polymer | 99 | 11097.8 | 1 | UniProt (Q02370) | Bos taurus (domestic cattle) | Complex I-B8,CI-B8,NADH-ubiquinone oxidoreductase B8 subunit |
| 20 | T, U (T, U) | Acyl carrier protein, mitochondrial | polymer | 156 | 17421.3 | 2 | UniProt (P52505) | Bos taurus (domestic cattle) | ACP,CI-SDAP,NADH-ubiquinone oxidoreductase 9.6 kDa subunit |
| 21 | V (V) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 5 | polymer | 116 | 13334.6 | 1 | UniProt (P23935) | Bos taurus (domestic cattle) | Complex I subunit B13,Complex I-13kD-B,CI-13kD-B,NADH-ubiquinone oxidoreductase 13 kDa-B subunit |
| 22 | W (W) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 6 | polymer | 128 | 15083.5 | 1 | UniProt (Q02366) | Bos taurus (domestic cattle) | Complex I-B14,CI-B14,NADH-ubiquinone oxidoreductase B14 subunit |
| 23 | X (X) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 8 | polymer | 172 | 20124.1 | 1 | UniProt (P42029) | Bos taurus (domestic cattle) | Complex I-19kD,CI-19kD,Complex I-PGIV,CI-PGIV,NADH-ubiquinone oxidoreductase 19 kDa subunit |
| 24 | Y (Y) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 11 | polymer | 141 | 14666.9 | 1 | UniProt (Q8HXG6) | Bos taurus (domestic cattle) | Complex I-B14.7,CI-B14.7,NADH-ubiquinone oxidoreductase subunit B14.7 |
| 25 | Z (Z) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 13 | polymer | 144 | 16694.4 | 1 | UniProt (Q95KV7) | Bos taurus (domestic cattle) | Cell death regulatory protein GRIM-19,Complex I-B16.6,CI-B16.6,Gene associated with retinoic-interferon-induced mortality 19 protein,GRIM-19,NADH-ubiquinone oxidoreductase B16.6 subunit |
| 26 | AA (a) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 | polymer | 70 | 8117.4 | 1 | UniProt (Q02377) | Bos taurus (domestic cattle) | Complex I-MWFE,CI-MWFE,NADH-ubiquinone oxidoreductase MWFE subunit |
| 27 | BA (b) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 | polymer | 84 | 9357.9 | 1 | UniProt (Q02371) | Bos taurus (domestic cattle) | Complex I-B9,CI-B9,NADH-ubiquinone oxidoreductase B9 subunit |
| 28 | CA (c) | NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial | polymer | 76 | 8796.2 | 1 | UniProt (Q02376) | Bos taurus (domestic cattle) | Complex I-KFYI,CI-KFYI,NADH-ubiquinone oxidoreductase KFYI subunit |
| 29 | DA (d) | NADH dehydrogenase [ubiquinone] 1 subunit C2 | polymer | 121 | 14143.3 | 1 | UniProt (Q02827) | Bos taurus (domestic cattle) | Complex I-B14.5b,CI-B14.5b,NADH-ubiquinone oxidoreductase subunit B14.5b |
| 30 | EA (e) | NADH dehydrogenase [ubiquinone] iron-sulfur protein 5 | polymer | 106 | 12694.7 | 1 | UniProt (Q02379) | Bos taurus (domestic cattle) | Complex I-15 kDa,CI-15 kDa,NADH-ubiquinone oxidoreductase 15 kDa subunit |
| 31 | FA (f) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 1 | polymer | 57 | 6978.1 | 1 | UniProt (Q02378) | Bos taurus (domestic cattle) | Complex I-MNLL,CI-MNLL,NADH-ubiquinone oxidoreductase MNLL subunit |
| 32 | GA (g) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 11, mitochondrial | polymer | 154 | 17594.9 | 1 | UniProt (Q8HXG5) | Bos taurus (domestic cattle) | Complex I-ESSS,CI-ESSS,NADH-ubiquinone oxidoreductase ESSS subunit |
| 33 | HA (h) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial | polymer | 189 | 21624.1 | 1 | UniProt (Q02380) | Bos taurus (domestic cattle) | Complex I-SGDH,CI-SGDH,NADH-ubiquinone oxidoreductase SGDH subunit |
| 34 | IA (i) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 6 | polymer | 128 | 15444.9 | 1 | UniProt (Q02367) | Bos taurus (domestic cattle) | Complex I-B17,CI-B17,NADH-ubiquinone oxidoreductase B17 subunit |
| 35 | JA (j) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial | polymer | 108 | 12298.9 | 1 | UniProt (Q02374) | Bos taurus (domestic cattle) | Complex I-AGGG,CI-AGGG,NADH-ubiquinone oxidoreductase AGGG subunit |
| 36 | KA (k) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 3 | polymer | 98 | 11160.7 | 1 | UniProt (Q02365) | Bos taurus (domestic cattle) | Complex I-B12,CI-B12,NADH-ubiquinone oxidoreductase B12 subunit |
| 37 | LA (l) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial | polymer | 186 | 21678.5 | 1 | UniProt (Q02372) | Bos taurus (domestic cattle) | Complex I-ASHI,CI-ASHI,NADH-ubiquinone oxidoreductase ASHI subunit |
| 38 | MA (m) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 | polymer | 129 | 15206.3 | 1 | UniProt (P48305) | Bos taurus (domestic cattle) | Complex I-B15,CI-B15,NADH-ubiquinone oxidoreductase B15 subunit |
| 39 | NA (n) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 9 | polymer | 179 | 21827.9 | 1 | UniProt (Q02369) | Bos taurus (domestic cattle) | Complex I-B22,CI-B22,NADH-ubiquinone oxidoreductase B22 subunit |
| 40 | OA (o) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7 | polymer | 137 | 16428.8 | 1 | UniProt (Q02368) | Bos taurus (domestic cattle) | Complex I-B18,CI-B18,NADH-ubiquinone oxidoreductase B18 subunit |
| 41 | PA (p) | NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 10 | polymer | 176 | 21000.9 | 1 | UniProt (Q02373) | Bos taurus (domestic cattle) | Complex I-PDSW,CI-PDSW,NADH-ubiquinone oxidoreductase PDSW subunit |
| 42 | QA (q) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 | polymer | 145 | 17115.5 | 1 | UniProt (O97725) | Bos taurus (domestic cattle) | Complex I-B17.2,CIB17.2,NADH-ubiquinone oxidoreductase subunit B17.2 |
| 43 | RA (r) | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 7 | polymer | 113 | 12590.4 | 1 | UniProt (Q05752) | Bos taurus (domestic cattle) | Complex I-B14.5a,CI-B14.5a,NADH-ubiquinone oxidoreductase subunit B14.5a |
| 44 | SA (s) | NADH dehydrogenase [ubiquinone] flavoprotein 3, mitochondrial | polymer | 109 | 11874.5 | 1 | UniProt (P25712) | Bos taurus (domestic cattle) | Complex I-9kD,CI-9kD,NADH-ubiquinone oxidoreductase 9 kDa subunit |
| 45 | CC, IB, JB, JC, KC... (N, H, X, Y, I...) | 1,2-Distearoyl-sn-glycerophosphoethanolamine | non-polymer | 748.1 | 27 | Chemie (3PE) | |||
| 46 | BC, NB, SC, VA, WB... (N, J, d, B, M) | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 790.1 | 7 | Chemie (PC1) PubChem (65146) PubChem (94190) PubChem (10417837) | |||
| 47 | CB, EB, FB, KB, LB... (F, G, I, B) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 6 | Chemie (SF4) | |||
| 48 | YA (D) | DODECYL-BETA-D-MALTOSIDE | non-polymer | 510.6 | 1 | Chemie (LMT) | |||
| 49 | AB, GB (E, G) | FE2/S2 (INORGANIC) CLUSTER | non-polymer | 175.8 | 2 | Chemie (FES) | |||
| 50 | BB (F) | FLAVIN MONONUCLEOTIDE | non-polymer | 456.3 | 1 | Chemie (FMN) PubChem (710) PubChem (23585816) PubChem (8965) PubChem (51435500) PubChem (51435503) PubChem (643976) PubChem (5702760) PubChem (7048779) PubChem (7048781) PubChem (15559251) | |||
| 51 | DB (F) | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE | non-polymer | 665.4 | 1 | Chemie (NAI) PubChem (16219774) PubChem (928) PubChem (44119956) PubChem (44415182) PubChem (439153) PubChem (124934832) PubChem (126455899) PubChem (94865921) PubChem (94865923) PubChem (134693949) PubChem (12309339) PubChem (12309347) PubChem (124432988) PubChem (140875346) PubChem (11250888) PubChem (12309341) PubChem (124934831) PubChem (124934833) PubChem (162951601) PubChem (162951600) PubChem (164575491) PubChem (169545638) PubChem (170905224) PubChem (174316169) PubChem (129607000) PubChem (129628338) PubChem (146167236) PubChem (162951602) PubChem (174084875) | |||
| 52 | HB (G) | POTASSIUM ION | non-polymer | 39.1 | 1 | Chemie (K) PubChem (813) | |||
| 53 | AC, QB, TC, UC, ZC (N, L, d, h, q) | CARDIOLIPIN | non-polymer | 1464.0 | 5 | Chemie (CDL) PubChem (17753886) PubChem (5287898) | |||
| 54 | SB (L) | CHOLIC ACID | non-polymer | 408.6 | 1 | Chemie (CHD) PubChem (16401672) PubChem (16758100) PubChem (18528842) PubChem (20638765) PubChem (303) PubChem (23636694) PubChem (23640631) PubChem (6676) PubChem (23876184) PubChem (24836753) PubChem (24883735) PubChem (43835083) PubChem (16401251) PubChem (44135469) PubChem (44629918) PubChem (44657327) PubChem (21139644) PubChem (45114537) PubChem (45382168) PubChem (122340) PubChem (1762378) PubChem (46397523) PubChem (46783697) PubChem (49791911) PubChem (49796810) PubChem (50989873) PubChem (51432410) PubChem (51546373) PubChem (53298695) PubChem (53393606) PubChem (53477699) PubChem (160636) PubChem (221493) PubChem (57937243) PubChem (44339334) PubChem (58133002) PubChem (58582306) PubChem (376829) PubChem (439520) PubChem (58984417) PubChem (59032051) PubChem (59316662) PubChem (59877711) PubChem (59963674) PubChem (59997751) PubChem (60076012) PubChem (60098994) PubChem (60114995) PubChem (440427) PubChem (46780112) PubChem (66678354) PubChem (68097396) PubChem (68131418) PubChem (68318251) PubChem (68338620) PubChem (68372213) PubChem (71260265) PubChem (70649328) PubChem (70824975) PubChem (70930320) PubChem (70930789) PubChem (70960845) PubChem (637625) PubChem (59130005) PubChem (59381614) PubChem (59903914) PubChem (67122255) PubChem (3246132) PubChem (69904012) PubChem (130213) PubChem (145883) PubChem (70866085) PubChem (71001249) PubChem (239672) PubChem (71314856) PubChem (71752895) PubChem (5283869) PubChem (5283870) PubChem (5283871) PubChem (5283873) PubChem (5283875) PubChem (5283877) PubChem (5283878) PubChem (74765127) PubChem (89830646) PubChem (5302608) PubChem (5315844) PubChem (91128541) PubChem (91810856) PubChem (5283876) PubChem (5283879) PubChem (5283880) PubChem (5283872) PubChem (5283874) PubChem (98044963) PubChem (99565617) PubChem (122645815) PubChem (124161889) PubChem (124318072) PubChem (124488681) PubChem (125037036) PubChem (126577457) PubChem (129274856) PubChem (129274855) PubChem (129359810) PubChem (6708709) PubChem (6850901) PubChem (6850905) PubChem (99564899) PubChem (99565857) PubChem (133135020) PubChem (133126746) PubChem (11350342) PubChem (117684834) PubChem (117767695) PubChem (117944573) PubChem (118241311) PubChem (9802771) PubChem (121232934) PubChem (9846429) PubChem (9866174) PubChem (122537896) PubChem (122537897) PubChem (122644681) PubChem (122644923) PubChem (122646384) PubChem (12303168) PubChem (13020196) PubChem (71172094) PubChem (124328806) PubChem (124364505) PubChem (124425250) PubChem (124488680) PubChem (124511215) PubChem (124518077) PubChem (124518078) PubChem (124518446) PubChem (124761950) PubChem (12080557) PubChem (12303167) PubChem (12303172) PubChem (12303175) PubChem (12303178) PubChem (12303180) PubChem (13020205) PubChem (124841930) PubChem (124896923) PubChem (124896924) PubChem (124896925) PubChem (124896926) PubChem (124904187) PubChem (124904188) PubChem (124906682) PubChem (124906683) PubChem (124914603) PubChem (124914604) PubChem (124914605) PubChem (124914606) PubChem (125027431) PubChem (125037037) PubChem (162771689) PubChem (163059393) PubChem (163059399) PubChem (163059389) PubChem (126422551) PubChem (126422552) PubChem (126577461) PubChem (126672319) PubChem (166858402) PubChem (126969154) PubChem (129106816) PubChem (129460958) PubChem (129600748) PubChem (129628082) PubChem (130220803) PubChem (131700165) PubChem (132441695) PubChem (133548348) PubChem (133612061) PubChem (133655733) PubChem (133687870) PubChem (133688934) PubChem (134462403) PubChem (134555902) PubChem (134866321) PubChem (135373095) PubChem (137474142) PubChem (138107312) PubChem (139248576) PubChem (139291795) PubChem (139372812) PubChem (140618124) PubChem (141854542) PubChem (142134118) PubChem (143658950) PubChem (144316980) PubChem (145264188) PubChem (145714625) PubChem (146030145) PubChem (146665897) PubChem (154033190) PubChem (154036252) PubChem (154747009) PubChem (154825357) PubChem (155275443) PubChem (155605940) PubChem (157048615) PubChem (157269375) PubChem (157351909) PubChem (157383333) PubChem (158041002) PubChem (158420924) PubChem (158675416) PubChem (160081178) PubChem (160743345) PubChem (160917187) PubChem (161973449) PubChem (163059390) PubChem (163059391) PubChem (163059392) PubChem (163059394) PubChem (163059395) PubChem (163059396) PubChem (163059397) PubChem (163059398) PubChem (163059400) PubChem (163452349) PubChem (163452350) PubChem (163452351) PubChem (167344826) PubChem (168841979) PubChem (168841990) PubChem (168845540) PubChem (169410142) PubChem (169436432) PubChem (171721516) PubChem (157060709) | |||
| 55 | DC (O) | 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (DGT) PubChem (177678918) PubChem (136110594) PubChem (135398599) PubChem (135402022) PubChem (135566345) PubChem (136254580) PubChem (136633653) PubChem (136828797) PubChem (136828798) PubChem (137226754) PubChem (137257907) PubChem (171699498) | |||
| 56 | EC (O) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 57 | FC (P) | NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 745.4 | 1 | Chemie (NDP) | |||
| 58 | GC (R) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 59 | HC, IC (T, U) | ~{S}-[2-[3-[[(2~{R})-3,3-dimethyl-2-oxidanyl-4-phosphonooxy-butanoyl]amino]propanoylamino]ethyl] (3~{S})-3-oxidanyltetradecanethioate | non-polymer | 584.7 | 2 | Chemie (EHZ) PubChem (71777704) PubChem (137349255) PubChem (163183360) | |||
| 60 | YC (o) | MYRISTIC ACID | non-polymer | 228.4 | 1 | Chemie (MYR) PubChem (11005) | |||
| 61 | AD, AE, BD, BE, CD... (A, b, B, c, C...) | water | water | 18.0 | 3797 | Chemie (HOH) |
Sequence modifications
D: -32 - 430 (UniProt: P17694)
O: -22 - 320 (UniProt: P34942)
Y: 1 - 140 (UniProt: Q8HXG6)
d: 1 - 120 (UniProt: Q02827)
i: 1 - 127 (UniProt: Q02367)
r: 1 - 112 (UniProt: Q05752)
| PDB | External Database | Details |
|---|---|---|
| Arg 129 | Gln 162 | variant |
| PDB | External Database | Details |
|---|---|---|
| Lys 255 | Asn 278 | variant |
| PDB | External Database | Details |
|---|---|---|
| Ace 1 | - | acetylation |
| PDB | External Database | Details |
|---|---|---|
| Ace 1 | - | acetylation |
| PDB | External Database | Details |
|---|---|---|
| Ace 1 | - | acetylation |
| PDB | External Database | Details |
|---|---|---|
| Ace 1 | - | acetylation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 45 |
| Total formula weight | 1044196.7 | |
| Non-Polymers* | Number of molecules | 59 |
| Total formula weight | 40330.6 | |
| All* | Total formula weight | 1084527.3 |
