9SHY
Cryo-EM structure of the catalytic core of human telomerase at the initiation state of the repeat addition cycle
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Telomerase reverse transcriptase | polymer | 1132 | 127195.8 | 1 | UniProt (O14746) | Homo sapiens (human) | HEST2,Telomerase catalytic subunit,Telomerase-associated protein 2,TP2 |
| 2 | B (L) | Histone H2A | polymer | 130 | 14140.6 | 1 | UniProt (B2R5B3) | Homo sapiens (human) | |
| 3 | C (M) | Histone H2B | polymer | 166 | 18074.9 | 1 | UniProt (B4DR52) | Homo sapiens (human) | |
| 4 | D (N) | DNA (5'-D(P*TP*TP*AP*GP*GP*GP*TP*TP*AP*G)-3') | polymer | 34 | 10751.9 | 1 | Homo sapiens | ||
| 5 | E (O) | Adrenocortical dysplasia protein homolog | polymer | 458 | 49013.1 | 1 | UniProt (Q96AP0) | Homo sapiens (human) | POT1 and TIN2-interacting protein |
| 6 | F (B) | hTR, human telomerase RNA | polymer | 451 | 145477.8 | 1 | GenBank (1932797) | Homo sapiens (human) | |
| 7 | G (A) | 2'-deoxy-5'-O-[(R)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]guanosine | non-polymer | 505.2 | 1 | Chemie (1GC) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 364654.1 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 505.2 | |
| All* | Total formula weight | 365159.3 |
