9SFG
Crystal structure of NLRP3 in complex with inhibitor NP3-742
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NACHT, LRR and PYD domains-containing protein 3 | polymer | 550 | 64156.3 | 1 | UniProt (Q96P20) Pfam (PF14484) Pfam (PF05729) Pfam (PF17779) Pfam (PF17776) | Homo sapiens (human) | Angiotensin/vasopressin receptor AII/AVP-like,Caterpiller protein 1.1,CLR1.1,Cold-induced autoinflammatory syndrome 1 protein,Cryopyrin,PYRIN-containing APAF1-like protein 1 |
| 2 | B (A) | 5-methyl-~{N}-[(3~{R})-1-methylpiperidin-3-yl]-6-(2-methyl-1~{H}-pyrrolo[2,3-b]pyridin-6-yl)pyridazin-3-amine | non-polymer | 336.4 | 1 | Chemie (A1JNK) | |||
| 3 | C (A) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D (A) | water | water | 18.0 | 21 | Chemie (HOH) |
Sequence modifications
A: 131 - 679 (UniProt: Q96P20)
| PDB | External Database | Details |
|---|---|---|
| Gly 130 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 64156.3 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 763.6 | |
| All* | Total formula weight | 64919.9 |
