9SDX
Structure of RBR binding E2 variant crosslinked with NEDD8-CUL5-RBX2 bound ARIH2 and Ub
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (N) | NEDD8 | polymer | 81 | 9086.6 | 1 | UniProt (Q15843) Pfam (PF00240) | Homo sapiens (human) | Neddylin,Neural precursor cell expressed developmentally down-regulated protein 8,NEDD-8,Ubiquitin-like protein Nedd8 |
| 2 | B (R) | RING-box protein 2 | polymer | 113 | 12697.4 | 1 | UniProt (Q9UBF6) Pfam (PF12678) | Homo sapiens (human) | Rbx2,CKII beta-binding protein 1,CKBBP1,RING finger protein 7,Regulator of cullins 2,Sensitive to apoptosis gene protein |
| 3 | C (U) | Ubiquitin | polymer | 75 | 8519.8 | 1 | UniProt (P0CG48) Pfam (PF00240) | Homo sapiens (human) | |
| 4 | D (G) | L3A2-1 | polymer | 157 | 17998.6 | 1 | synthetic construct | ||
| 5 | E (C) | Cullin-5 | polymer | 780 | 91085.3 | 1 | UniProt (Q93034) Pfam (PF00888) Pfam (PF10557) | Homo sapiens (human) | CUL-5,Vasopressin-activated calcium-mobilizing receptor 1,VACM-1 |
| 6 | F (H) | E3 ubiquitin-protein ligase ARIH2 | polymer | 493 | 57893.8 | 1 | UniProt (O95376) Pfam (PF00097) Pfam (PF01485) Pfam (PF22191) Pfam (PF19422) | Homo sapiens (human) | ARI-2,Protein ariadne-2 homolog,RING-type E3 ubiquitin transferase ARIH2,Triad1 protein |
| 7 | G, H, I, K, L... (R, H) | ZINC ION | non-polymer | 65.4 | 7 | Chemie (ZN) | |||
| 8 | J (U) | 5-azanylpentan-2-one | non-polymer | 101.1 | 1 | Chemie (SY8) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 6 |
| Total formula weight | 197281.5 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 559.0 | |
| All* | Total formula weight | 197840.5 |
