9S9R
Crystal structure of p53 cancer mutant Y220N
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cellular tumor antigen p53 | polymer | 219 | 24541.8 | 2 | UniProt (P04637) Pfam (PF00870) | Homo sapiens (human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | C, F (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, E, G, H, I (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 4 | J, K (A, B) | water | water | 18.0 | 343 | Chemie (HOH) |
Sequence modifications
A, B: 94 - 312 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Leu 133 | Met 133 | engineered mutation |
| Ala 203 | Val 203 | engineered mutation |
| Asn 220 | Tyr 220 | engineered mutation |
| Tyr 239 | Asn 239 | engineered mutation |
| Asp 268 | Asn 268 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49083.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 441.2 | |
| All* | Total formula weight | 49524.7 |
