9S9P
Crystal structure of p53 cancer mutant Y220S in complex with rezatapopt
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cellular tumor antigen p53 | polymer | 219 | 24514.7 | 2 | UniProt (P04637) | Homo sapiens (human) | Antigen NY-CO-13,Phosphoprotein p53,Tumor suppressor p53 |
| 2 | C, N (A, B) | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
| 3 | D, O (A, B) | 4-[3-[4-[[(3~{S},4~{R})-3-fluoranyl-1-methyl-piperidin-4-yl]amino]-1-[2,2,2-tris(fluoranyl)ethyl]indol-2-yl]prop-2-ynylamino]-3-methoxy-~{N}-methyl-benzamide | non-polymer | 545.6 | 2 | Chemie (A1JMR) | |||
| 4 | AA, E, F, G, I... (B, A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 16 | Chemie (EDO) | |||
| 5 | H, K, L, U, V (A, B) | NITRATE ION | non-polymer | 62.0 | 5 | Chemie (NO3) | |||
| 6 | BA, CA (A, B) | water | water | 18.0 | 491 | Chemie (HOH) |
Sequence modifications
A, B: 94 - 312 (UniProt: P04637)
| PDB | External Database | Details |
|---|---|---|
| Leu 133 | Met 133 | engineered mutation |
| Ala 203 | Val 203 | engineered mutation |
| Ser 220 | Tyr 220 | engineered mutation |
| Tyr 239 | Asn 239 | engineered mutation |
| Asp 268 | Asn 268 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 49029.5 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 2525.1 | |
| All* | Total formula weight | 51554.6 |
