9S8W
Human heparanase in complex with neutralizing antibody A54 Fab fragment
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Heparanase | polymer | 386 | 43464.1 | 1 | UniProt (Q9Y251) Pfam (PF03662) | Homo sapiens (human) | Endo-glucoronidase,Heparanase-1,Hpa1 |
| 2 | B (B) | Heparanase 8 kDa subunit | polymer | 74 | 8273.5 | 1 | UniProt (Q9Y251) | Homo sapiens (human) | |
| 3 | C (H) | A54 Fab heavy chain | polymer | 222 | 23921.6 | 1 | Mus musculus | ||
| 4 | D (L) | A54 Fab light chain | polymer | 218 | 24027.4 | 1 | Mus musculus | ||
| 5 | E (C) | alpha-L-fucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 367.3 | 1 | In PDB GlyTouCan (G86851RC) | |||
| 6 | F, G, H (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) | |||
| 7 | I, J, K, L (A, B, H, L) | water | water | 18.0 | 31 | Chemie (HOH) |
Sequence modifications
A: 158 - 543 (UniProt: Q9Y251)
| PDB | External Database | Details |
|---|---|---|
| Arg 307 | Lys 307 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 99686.6 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 367.3 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 100717.5 |
