9S84
Crystal structure of KRAS G12D D38C (GDP-bound)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog, isoform CRA_b | polymer | 170 | 19352.8 | 1 | UniProt (A0ABF7PHA5) | Homo sapiens (human) | |
| 2 | B (A) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 1 | Chemie (GDP) | |||
| 3 | C (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) PubChem (888) | |||
| 4 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | E (A) | NITRATE ION | non-polymer | 62.0 | 1 | Chemie (NO3) PubChem (943) | |||
| 6 | F (A) | water | water | 18.0 | 258 | Chemie (HOH) |
Sequence modifications
A: 1 - 169 (UniProt: A0ABF7PHA5)
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Asp 12 | Gly 12 | engineered mutation |
| Cys 38 | Asp 38 | engineered mutation |
| Ser 51 | Cys 51 | conflict |
| Leu 80 | Cys 80 | conflict |
| Ser 118 | Cys 118 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 19352.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 591.6 | |
| All* | Total formula weight | 19944.4 |
