9S7T
Crystal structure of Aurora-A bound to DBS5
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Aurora kinase A | polymer | 285 | 32883.7 | 2 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (human) | Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,Breast tumor-amplified kinase,Ipl1- and aurora-related kinase 1,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase Ayk1,Serine/threonine-protein kinase aurora-A |
| 2 | B, D (B, D) | DBS5 | polymer | 92 | 10549.0 | 2 | unidentified | ||
| 3 | E, I (A, C) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 4 | F (A) | TRIS(HYDROXYETHYL)AMINOMETHANE | non-polymer | 163.2 | 1 | Chemie (TAM) PubChem (448009) | |||
| 5 | G, J (A, C) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | H (A) | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) PubChem (271) | |||
| 7 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 241 | Chemie (HOH) |
Sequence modifications
A, C: 122 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 119 | - | expression tag |
| Ala 120 | - | expression tag |
| Met 121 | - | expression tag |
| Asn 274 | Asp 274 | conflict |
| Ala 290 | Cys 290 | conflict |
| Ala 393 | Cys 393 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 86865.4 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1106.3 | |
| All* | Total formula weight | 87971.7 |
