9S2V
NSP14 IN COMPLEX WITH LIGAND TDI-014925-CL-2 (compound 58)
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Guanine-N7 methyltransferase nsp14 | polymer | 528 | 59872.5 | 2 | UniProt (P0DTD1) Pfam (PF06471) | SARS-CoV-2 pseudovirus | Non-structural protein 14,nsp14,Proofreading exoribonuclease nsp14,ExoN |
| 2 | C, D, E, L, M... (A, B) | ZINC ION | non-polymer | 65.4 | 6 | Chemie (ZN) | |||
| 3 | F, O (A, B) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 2 | Chemie (SAH) | |||
| 4 | G, P (A, B) | ~{N}-[(6-fluoranyl-1-methyl-indazol-7-yl)methyl]-1,5-dimethyl-4-(1,4,6,7-tetrahydropyrazolo[4,3-c]pyridin-5-ylsulfonyl)pyrrole-2-carboxamide | non-polymer | 485.5 | 2 | Chemie (A1JLH) | |||
| 5 | H, I, J, Q, R (A, B) | CHLORIDE ION | non-polymer | 35.5 | 5 | Chemie (CL) | |||
| 6 | K, S (A, B) | IMIDAZOLE | non-polymer | 69.1 | 2 | Chemie (IMD) | |||
| 7 | T, U (A, B) | water | water | 18.0 | 207 | Chemie (HOH) |
Sequence modifications
A, B: 1 - 527 (UniProt: P0DTD1)
| PDB | External Database | Details |
|---|---|---|
| Ser 0 | - | expression tag |
| Ala 90 | Asp 6015 | engineered mutation |
| Ala 92 | Glu 6017 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 119745.0 | |
| Non-Polymers* | Number of molecules | 17 |
| Total formula weight | 2447.8 | |
| All* | Total formula weight | 122192.8 |
