9S2I
Ternary structure of 14-3-3, CRAF R256S NS mutant phosphopeptide (pS259), and compound 78 (1124378)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 14-3-3 protein sigma | polymer | 236 | 26542.9 | 1 | UniProt (P31947) Pfam (PF00244) | Homo sapiens (human) | Epithelial cell marker protein 1,Stratifin |
| 2 | B (P) | RAF proto-oncogene serine/threonine-protein kinase | polymer | 11 | 1269.3 | 1 | UniProt (P04049) | Homo sapiens | Proto-oncogene c-RAF,cRaf,Raf-1 |
| 3 | C (A) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 4 | D, E (A) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 5 | F (A) | 1-[8-(4-bromophenyl)sulfonyl-5-oxa-2,8-diazaspiro[3.5]nonan-2-yl]-2-chloranyl-ethanone | non-polymer | 423.7 | 1 | Chemie (WQN) PubChem (176404668) | |||
| 6 | G, H (A, P) | water | water | 18.0 | 234 | Chemie (HOH) |
Sequence modifications
A: 1 - 231 (UniProt: P31947)
P: 255 - 265 (UniProt: P04049)
| PDB | External Database | Details |
|---|---|---|
| Gly -4 | - | expression tag |
| Ala -3 | - | expression tag |
| Met -2 | - | expression tag |
| Gly -1 | - | expression tag |
| Ser 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ser 256 | Arg 256 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27812.2 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 507.8 | |
| All* | Total formula weight | 28319.9 |
