9S23
Crystal structure of human SIRT2 in complex with peptide triazole inhibitor OTDi1
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | NAD-dependent protein deacetylase sirtuin-2 | polymer | 304 | 34416.7 | 1 | UniProt (Q8IXJ6) Pfam (PF02146) | Homo sapiens (human) | Regulatory protein SIR2 homolog 2,SIR2-like protein 2 |
| 2 | B (C) | TNFa-derived ornithine triazole dodecyl inhibitor | polymer | 9 | 843.9 | 1 | Homo sapiens | ||
| 3 | C (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 5 | E (C) | 4-dodecyl-1-ethyl-1,2,3-triazole | non-polymer | 265.4 | 1 | Chemie (A1JK5) | |||
| 6 | F, G (A, C) | water | water | 18.0 | 34 | Chemie (HOH) |
Sequence modifications
A: 56 - 356 (UniProt: Q8IXJ6)
| PDB | External Database | Details |
|---|---|---|
| Gly 53 | - | expression tag |
| His 54 | - | expression tag |
| Met 55 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 35260.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 392.9 | |
| All* | Total formula weight | 35653.6 |
