9S18
WRN helicase in complex with HRO761
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | polymer | 443 | 50635.3 | 1 | UniProt (Q14191) Pfam (PF00270) Pfam (PF00271) Pfam (PF16124) | Homo sapiens (human) | DNA helicase,RecQ-like type 3,RecQ protein-like 2,Werner syndrome protein |
| 2 | B, D, I (A) | CITRATE ANION | non-polymer | 189.1 | 3 | Chemie (FLC) PubChem (31348) | |||
| 3 | C, E, H, K (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 4 | Chemie (EDO) | |||
| 4 | F (A) | ~{N}-[2-chloranyl-4-(trifluoromethyl)phenyl]-2-[2-(3,6-dihydro-2~{H}-pyran-4-yl)-5-ethyl-6-[4-(6-methyl-5-oxidanyl-pyrimidin-4-yl)carbonylpiperazin-1-yl]-7-oxidanylidene-[1,2,4]triazolo[1,5-a]pyrimidin-4-yl]ethanamide | non-polymer | 702.1 | 1 | Chemie (YHC) PubChem (166140536) | |||
| 5 | G (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 1 | Chemie (DMS) PubChem (679) | |||
| 6 | J (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) PubChem (8117) | |||
| 7 | L (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) PubChem (32051) | |||
| 8 | M (A) | water | water | 18.0 | 175 | Chemie (HOH) |
Sequence modifications
A: 517 - 943 (UniProt: Q14191)
| PDB | External Database | Details |
|---|---|---|
| Met 501 | - | initiating methionine |
| Gly 502 | - | expression tag |
| His 503 | - | expression tag |
| His 504 | - | expression tag |
| His 505 | - | expression tag |
| His 506 | - | expression tag |
| His 507 | - | expression tag |
| His 508 | - | expression tag |
| Glu 509 | - | expression tag |
| Asn 510 | - | expression tag |
| Leu 511 | - | expression tag |
| Tyr 512 | - | expression tag |
| Phe 513 | - | expression tag |
| Gln 514 | - | expression tag |
| Gly 515 | - | expression tag |
| Ser 516 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 50635.3 | |
| Non-Polymers* | Number of molecules | 11 |
| Total formula weight | 1767.3 | |
| All* | Total formula weight | 52402.6 |
