9S14
Crystal structure of Aurora-A bound to DBS1
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DBS1 | polymer | 99 | 11543.2 | 1 | synthetic construct | ||
| 2 | B (B) | Aurora kinase A | polymer | 282 | 32624.3 | 1 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (human) | Aurora 2,Aurora/IPL1-related kinase 1,ARK-1,Aurora-related kinase 1,Breast tumor-amplified kinase,Ipl1- and aurora-related kinase 1,Serine/threonine-protein kinase 15,Serine/threonine-protein kinase 6,Serine/threonine-protein kinase Ayk1,Serine/threonine-protein kinase aurora-A |
| 3 | C (B) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 84 | Chemie (HOH) |
Sequence modifications
B: 122 - 403 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Asn 274 | Asp 274 | engineered mutation |
| Ala 290 | Cys 290 | engineered mutation |
| Ala 393 | Cys 393 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 44167.5 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 427.2 | |
| All* | Total formula weight | 44594.7 |
