9S0V
The Crystal Structure of Human Tissue Nonspecific Alkaline Phosphatase (hTNAP) in complex with phosphate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Alkaline phosphatase, tissue-nonspecific isozyme | polymer | 509 | 56454.0 | 5 | UniProt (P05186) Pfam (PF00245) | Homo sapiens (human) | AP-TNAP,TNS-ALP,TNSALP,Alkaline phosphatase liver/bone/kidney isozyme,Phosphoamidase,Phosphocreatine phosphatase |
| 2 | F, G, I, J, L... (F, G, I, J, L...) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 10 | In PDB GlyTouCan (G42666HT) | |||
| 3 | H, K, Q, S (H, K, Q, S) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 4 | In PDB GlyTouCan (G15407YE) | |||
| 4 | AA, FA, GA, LA, MA... (B, C, D, E, A) | ZINC ION | non-polymer | 65.4 | 10 | Chemie (ZN) | |||
| 5 | BA, HA, NA, TA, V (B, C, D, E, A) | MAGNESIUM ION | non-polymer | 24.3 | 5 | Chemie (MG) PubChem (888) | |||
| 6 | CA, IA, OA, UA, W (B, C, D, E, A) | CALCIUM ION | non-polymer | 40.1 | 5 | Chemie (CA) PubChem (271) | |||
| 7 | DA, JA, PA, VA, WA... (B, C, D, E, A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
| 8 | EA, KA, QA, XA, Y (B, C, D, E, A) | PHOSPHATE ION | non-polymer | 95.0 | 5 | Chemie (PO4) PubChem (1061) | |||
| 9 | AB, BB, YA, ZA (C, E, A, B) | water | water | 18.0 | 9 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 18 - 500 (UniProt: P05186)
| PDB | External Database | Details |
|---|---|---|
| Ala 501 | - | expression tag |
| Ala 502 | - | expression tag |
| Ala 503 | - | expression tag |
| Glu 504 | - | expression tag |
| Asn 505 | - | expression tag |
| Leu 506 | - | expression tag |
| Tyr 507 | - | expression tag |
| Phe 508 | - | expression tag |
| Gln 509 | - | expression tag |
| Gly 510 | - | expression tag |
| Asp 511 | - | expression tag |
| Tyr 512 | - | expression tag |
| Lys 513 | - | expression tag |
| Asp 514 | - | expression tag |
| Asp 515 | - | expression tag |
| Asp 516 | - | expression tag |
| Asp 517 | - | expression tag |
| Lys 518 | - | expression tag |
| His 519 | - | expression tag |
| His 520 | - | expression tag |
| His 521 | - | expression tag |
| His 522 | - | expression tag |
| His 523 | - | expression tag |
| His 524 | - | expression tag |
| His 525 | - | expression tag |
| His 526 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 282269.8 | |
| Branched | Number of molecules | 14 |
| Total formula weight | 6590.2 | |
| Non-Polymers* | Number of molecules | 31 |
| Total formula weight | 2778.1 | |
| All* | Total formula weight | 291638.1 |
