9RYC

Structure of human 1918 influenza A polymerase heterotrimer in complex with WSN NEP.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Polymerase acidic protein	polymer	716	82707.4	1	UniProt (Q3HM39) Pfam (PF00603)	Influenza A virus (A/Brevig Mission/1/1918(H1N1))	RNA-directed RNA polymerase subunit P2
2	B (B)	RNA-directed RNA polymerase catalytic subunit	polymer	757	86625.2	1	UniProt (Q3HM40) Pfam (PF00602)	Influenza A virus (A/Brevig Mission/1/1918(H1N1))	Polymerase basic protein 1,PB1,RNA-directed RNA polymerase subunit P1
3	C (C)	Polymerase basic protein 2	polymer	765	86849.1	1	UniProt (Q3HM41) Pfam (PF20947) Pfam (PF20948) Pfam (PF20949) Pfam (PF20950) Pfam (PF00604) Pfam (PF20951) Pfam (PF20952)	Influenza A virus (A/Brevig Mission/1/1918(H1N1))
4	D (D)	Nuclear export protein	polymer	130	15221.4	1	UniProt (Q77IX1) Pfam (PF00601)	Influenza A virus (A/Brevig Mission/1/1918(H1N1))	NEP,Non-structural protein 2,NS2

Sequence modifications

C: 1 - 759 (UniProt: Q3HM41)

PDB	External Database	Details
Glu 760	-	expression tag
Asn 761	-	expression tag
Leu 762	-	expression tag
Tyr 763	-	expression tag
Phe 764	-	expression tag
Gln 765	-	expression tag

D: 1 - 121 (UniProt: Q77IX1)

PDB	External Database	Details
Gly -8	-	expression tag
Pro -7	-	expression tag
Leu -6	-	expression tag
Gly -5	-	expression tag
Ser -4	-	expression tag
Pro -3	-	expression tag
Glu -2	-	expression tag
Phe -1	-	expression tag
Cys 0	-	expression tag
Ile 31	Met 31	conflict
Gly 70	Ser 70	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	271403.1
All*	Total formula weight	271403.1

*Water molecules are not included.