9RTI
Structure of WRN in complex with ATPgS and covalent ligand Compound 7
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN | polymer | 427 | 48597.1 | 1 | UniProt (Q14191) Pfam (PF00270) Pfam (PF00271) Pfam (PF16124) | Homo sapiens (human) | DNA helicase,RecQ-like type 3,RecQ protein-like 2,Werner syndrome protein |
| 2 | B (A) | PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | non-polymer | 523.2 | 1 | Chemie (AGS) | |||
| 3 | C, Z (A) | DIMETHYL SULFOXIDE | non-polymer | 78.1 | 2 | Chemie (DMS) | |||
| 4 | D, E, F, G, H... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 15 | Chemie (EDO) | |||
| 5 | K (A) | ~{N}-[1-[(4-fluorophenyl)methyl]-7-methyl-indazol-3-yl]propanamide | non-polymer | 311.4 | 1 | Chemie (A1JJ8) | |||
| 6 | O (A) | ~{N}-[1-[(4-fluorophenyl)methyl]-7-methyl-indazol-3-yl]prop-2-enamide | non-polymer | 309.3 | 1 | Chemie (A1JJQ) | |||
| 7 | P (A) | D-MALATE | non-polymer | 134.1 | 1 | Chemie (MLT) | |||
| 8 | AA, Q, U, V, Y (A) | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 5 | Chemie (PEG) | |||
| 9 | BA (A) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 10 | CA (A) | water | water | 18.0 | 203 | Chemie (HOH) |
Sequence modifications
A: 517 - 941 (UniProt: Q14191)
| PDB | External Database | Details |
|---|---|---|
| Gly 515 | - | expression tag |
| Met 516 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 48597.1 | |
| Non-Polymers* | Number of molecules | 27 |
| Total formula weight | 2961.3 | |
| All* | Total formula weight | 51558.4 |
