9RST

Cryo-EM structure of the Target of Rapamycin Complex 2 (TORC2) in autoinhibted conformation (monomer)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Serine/threonine-protein kinase TOR2	polymer	2474	281915.4	1	UniProt (P32600)	Saccharomyces cerevisiae (brewer's yeast)	Dominant rapamycin resistance protein 2,Phosphatidylinositol 4-kinase TOR2,PI4-kinase TOR2,PI4K TOR2,PtdIns-4-kinase TOR2,Target of rapamycin kinase 2,Temperature-sensitive CSG2 suppressor protein 14
2	B (B)	Target of rapamycin complex subunit LST8	polymer	303	34077.9	1	UniProt (P41318)	Saccharomyces cerevisiae (brewer's yeast)	TORC subunit LST8,Lethal with SEC13 protein 8
3	C, G (C, H)	Target of rapamycin complex 2 subunit TSC11	polymer	1430	164580.6	2	UniProt (P40061)	Saccharomyces cerevisiae (brewer's yeast)	TORC2 subunit TSC11,Adheres voraciously to TOR2 protein 3,Temperature-sensitive CSG2 suppressor protein 11
4	D (D)	Target of rapamycin complex 2 subunit AVO2	polymer	426	47206.5	1	UniProt (Q04749)	Saccharomyces cerevisiae (brewer's yeast)	TORC2 subunit AVO2,Adheres voraciously to TOR2 protein 2
5	E (E)	Target of rapamycin complex 2 subunit BIT61	polymer	543	60908.7	1	UniProt (P47041)	Saccharomyces cerevisiae (brewer's yeast)	TORC2 subunit BIT61,61 kDa binding partner of TOR2 protein
6	F (G)	Target of rapamycin complex 2 subunit AVO1	polymer	1176	131565.5	1	UniProt (Q08236)	Saccharomyces cerevisiae (brewer's yeast)	TORC2 subunit AVO1,Adheres voraciously to TOR2 protein 1
7	H (A)	INOSITOL HEXAKISPHOSPHATE	non-polymer		660.0	1	Chemie (IHP)

Contents of the asymmetric unit

Polymers	Number of chains	7
	Total formula weight	884835.1
Non-Polymers*	Number of molecules	1
	Total formula weight	660.0
All*	Total formula weight	885495.2

*Water molecules are not included.