9RS3
Crystal structure of the human METTL3-METTL14 in complex with compound 3
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | N6-adenosine-methyltransferase catalytic subunit | polymer | 228 | 26017.8 | 1 | UniProt (Q86U44) Pfam (PF05063) | Homo sapiens (human) | Methyltransferase-like protein 3,hMETTL3,N6-adenosine-methyltransferase 70 kDa subunit,MT-A70 |
| 2 | B (B) | N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 | polymer | 307 | 35690.4 | 1 | UniProt (Q9HCE5) Pfam (PF05063) | Homo sapiens (human) | Methyltransferase-like protein 14,hMETTL14 |
| 3 | C (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) PubChem (16760024) PubChem (193) PubChem (13792) PubChem (177678424) PubChem (189149) PubChem (439155) PubChem (25210495) PubChem (21125603) PubChem (44361184) PubChem (25203782) PubChem (46936206) PubChem (50989525) PubChem (51380914) PubChem (52224398) PubChem (57544532) PubChem (52224400) PubChem (59046843) PubChem (59170628) PubChem (59576228) PubChem (66805708) PubChem (5284331) PubChem (70689219) PubChem (70702054) PubChem (70832431) PubChem (71170554) PubChem (13231890) PubChem (6419189) PubChem (118374891) PubChem (118560068) PubChem (126969526) PubChem (129105892) PubChem (164157219) PubChem (143518505) PubChem (154578335) PubChem (163054214) PubChem (163335525) | |||
| 4 | D (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) PubChem (175) | |||
| 5 | E, F (B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | G (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 7 | H (B) | 4-[[[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-oxidanyl-phenyl]amino]methyl]-1-(4-phenylmethoxypyridin-2-yl)piperidin-4-ol | non-polymer | 530.7 | 1 | Chemie (A1JI7) | |||
| 8 | I, J (A, B) | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A: 354 - 580 (UniProt: Q86U44)
B: 107 - 395 (UniProt: Q9HCE5)
| PDB | External Database | Details |
|---|---|---|
| Met 353 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 89 | - | initiating methionine |
| His 90 | - | expression tag |
| His 91 | - | expression tag |
| His 92 | - | expression tag |
| His 93 | - | expression tag |
| His 94 | - | expression tag |
| His 95 | - | expression tag |
| Ser 96 | - | expression tag |
| Ser 97 | - | expression tag |
| Gly 98 | - | expression tag |
| Arg 99 | - | expression tag |
| Glu 100 | - | expression tag |
| Asn 101 | - | expression tag |
| Leu 102 | - | expression tag |
| Tyr 103 | - | expression tag |
| Phe 104 | - | expression tag |
| Gln 105 | - | expression tag |
| Gly 106 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 61708.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1058.2 | |
| All* | Total formula weight | 62766.5 |
