9RS3
Crystal structure of the human METTL3-METTL14 in complex with compound 3
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | N6-adenosine-methyltransferase catalytic subunit | polymer | 228 | 26017.8 | 1 | UniProt (Q86U44) Pfam (PF05063) | Homo sapiens (human) | Methyltransferase-like protein 3,hMETTL3,N6-adenosine-methyltransferase 70 kDa subunit,MT-A70 |
| 2 | B (B) | N(6)-adenosine-methyltransferase non-catalytic subunit METTL14 | polymer | 307 | 35690.4 | 1 | UniProt (Q9HCE5) Pfam (PF05063) | Homo sapiens (human) | Methyltransferase-like protein 14,hMETTL14 |
| 3 | C (A) | S-ADENOSYL-L-HOMOCYSTEINE | non-polymer | 384.4 | 1 | Chemie (SAH) PubChem (439155) | |||
| 4 | D (B) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) PubChem (175) | |||
| 5 | E, F (B) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) PubChem (888) | |||
| 6 | G (B) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) PubChem (312) | |||
| 7 | H (B) | 4-[[[4-[(4,4-dimethylpiperidin-1-yl)methyl]-2-oxidanyl-phenyl]amino]methyl]-1-(4-phenylmethoxypyridin-2-yl)piperidin-4-ol | non-polymer | 530.7 | 1 | Chemie (A1JI7) | |||
| 8 | I, J (A, B) | water | water | 18.0 | 89 | Chemie (HOH) |
Sequence modifications
A: 354 - 580 (UniProt: Q86U44)
B: 107 - 395 (UniProt: Q9HCE5)
| PDB | External Database | Details |
|---|---|---|
| Met 353 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Met 89 | - | initiating methionine |
| His 90 | - | expression tag |
| His 91 | - | expression tag |
| His 92 | - | expression tag |
| His 93 | - | expression tag |
| His 94 | - | expression tag |
| His 95 | - | expression tag |
| Ser 96 | - | expression tag |
| Ser 97 | - | expression tag |
| Gly 98 | - | expression tag |
| Arg 99 | - | expression tag |
| Glu 100 | - | expression tag |
| Asn 101 | - | expression tag |
| Leu 102 | - | expression tag |
| Tyr 103 | - | expression tag |
| Phe 104 | - | expression tag |
| Gln 105 | - | expression tag |
| Gly 106 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 61708.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1058.2 | |
| All* | Total formula weight | 62766.5 |
