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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

9RPB

a5b3 GABAAR bound to GABA, and Mb25 in a desensitized state in saposin nanodiscs, topiramate-free

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, D
(A, D)		Green fluorescent protein,Gamma-aminobutyric acid receptor subunit alpha-5polymer67976207.32UniProt (P42212)
UniProt (P31644)		Aequorea victoriaGABA(A) receptor subunit alpha-5,GABAAR subunit alpha-5
2B, C, E
(B, C, E)		Gamma-aminobutyric acid receptor subunit beta-3,Green fluorescent proteinpolymer62371073.43UniProt (P28472)
UniProt (P42212)		Homo sapiens (human)GABA(A) receptor subunit beta-3,GABAAR subunit beta-3
3F
(P)		Outer membrane proteinpolymer54158275.11UniProt (B5Z8H1)Escherichia coli
4G
(F)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.41In PDB
GlyTouCan (G42666HT)
5H, J, N
(G, I, M)		beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched586.53In PDB
GlyTouCan (G15407YE)
6I, O
(H, N)		alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched1073.02In PDB
GlyTouCan (G09724ZC)
7K
(J)		beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched586.51In PDB
GlyTouCan (G44266EX)
8L
(K)		alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched1073.01In PDB
9M
(L)		2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranosebranched424.41In PDB
GlyTouCan (G35932AR)
10P, S
(B, E)		GAMMA-AMINO-BUTANOIC ACIDnon-polymer103.12Chemie (ABU)
11Q
(C)		4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACIDnon-polymer238.31Chemie (EPE)
12R
(D)		2-acetamido-2-deoxy-beta-D-glucopyranosenon-polymer221.21Chemie (NAG)
Sequence modifications
A, D: -287 - -50 (UniProt: P42212)
PDBExternal DatabaseDetails
Met -315-initiating methionine
Arg -314-expression tag
Lys -313-expression tag
Ser -312-expression tag
Pro -311-expression tag
Gly -310-expression tag
Leu -309-expression tag
Ser -308-expression tag
Asp -307-expression tag
Cys -306-expression tag
Leu -305-expression tag
Trp -304-expression tag
Ala -303-expression tag
Trp -302-expression tag
Ile -301-expression tag
Leu -300-expression tag
Leu -299-expression tag
Leu -298-expression tag
Ser -297-expression tag
Thr -296-expression tag
Leu -295-expression tag
Thr -294-expression tag
Gly -293-expression tag
Arg -292-expression tag
Ser -291-expression tag
Tyr -290-expression tag
Gly -289-expression tag
Gln -288-expression tag
Arg -258Ser 30conflict
Asn -249Tyr 39conflict
Leu -224Phe 64conflict
Thr -223Ser 65conflict
Arg -208Gln 80conflict
Ser -189Phe 99conflict
Thr -183Asn 105conflict
Phe -143Tyr 145conflict
Thr -135Met 153conflict
Ala -125Val 163conflict
Val -117Ile 171conflict
Val -82Ala 206conflict
Ala -49-linker
Ala -48-linker
Asn -47-linker
Ala -46-linker
Leu -45-linker
Ala -44-linker
Ala -43-linker
Trp -42-linker
Ser -41-linker
His -40-linker
Pro -39-linker
Gln -38-linker
Phe -37-linker
Glu -36-linker
Lys -35-linker
Gly -34-linker
Gly -33-linker
Gly -32-linker
Ser -31-linker
Gly -30-linker
Gly -29-linker
Gly -28-linker
Ser -27-linker
Gly -26-linker
Gly -25-linker
Gly -24-linker
Ser -23-linker
Trp -22-linker
Ser -21-linker
His -20-linker
Pro -19-linker
Gln -18-linker
Phe -17-linker
Glu -16-linker
Lys -15-linker
Ser -14-linker
Ser -13-linker
Ser -12-linker
Asn -11-linker
Asn -10-linker
Asn -9-linker
Asn -8-linker
Asn -7-linker
Glu -6-linker
Asn -5-linker
Leu -4-linker
Tyr -3-linker
Phe -2-linker
Gln -1-linker
Ala 0-linker
A, D: 1 - 314 (UniProt: P31644)
A, D: 322 - 363 (UniProt: P31644)
PDBExternal DatabaseDetails
Ser 315-linker
Gln 316-linker
Pro 317-linker
Ala 318-linker
Arg 319-linker
Ala 320-linker
Ala 321-linker
B, C, E: -24 - 307 (UniProt: P28472)
B, C, E: 316 - 552 (UniProt: P42212)
PDBExternal DatabaseDetails
Met 332Leu 18conflict
Arg 339His 25conflict
Arg 344Ser 30conflict
Val 346Glu 32conflict
His 353Tyr 39conflict
Ser 364Thr 50conflict
Leu 378Phe 64conflict
Ser 419Asn 105conflict
Val 438Glu 124conflict
Thr 442Ile 128conflict
Met 459Tyr 145conflict
Val 461Ser 147conflict
Gly 462His 148conflict
Thr 467Met 153conflict
Ala 477Val 163conflict
Glu 480Lys 166conflict
Val 485Ile 171conflict
Gly 489Ser 175conflict
Ser 506Pro 192conflict
Val 517Thr 203conflict
Val 519Ser 205conflict
Lys 520Ala 206conflict
Arg 538Val 224conflict
Pro 545His 231conflict
Gly 553-linker
Arg 554-linker
Ala 555-linker
Ala 556-linker
B, C, E: 557 - 583 (UniProt: P28472)
PDBExternal DatabaseDetails
Ser 308-linker
Gln 309-linker
Pro 310-linker
Gly 311-linker
Arg 312-linker
Ala 313-linker
Met 314-linker
Val 315-linker
Ser 584-expression tag
Arg 585-expression tag
Glu 586-expression tag
Asn 587-expression tag
Leu 588-expression tag
Tyr 589-expression tag
Phe 590-expression tag
Gln 591-expression tag
Ala 592-expression tag
His 593-expression tag
His 594-expression tag
His 595-expression tag
His 596-expression tag
His 597-expression tag
His 598-expression tag
P: 13 - 241 (UniProt: B5Z8H1)
PDBExternal DatabaseDetails
Met -18-initiating methionine
Lys -17-expression tag
Lys -16-expression tag
Ile -15-expression tag
Trp -14-expression tag
Leu -13-expression tag
Ala -12-expression tag
Leu -11-expression tag
Ala -10-expression tag
Gly -9-expression tag
Leu -8-expression tag
Val -7-expression tag
Leu -6-expression tag
Ala -5-expression tag
Phe -4-expression tag
Ser -3-expression tag
Ala -2-expression tag
Ser -1-expression tag
Ala 0-expression tag
Gln 1-expression tag
Val 2-expression tag
Gln 3-expression tag
Leu 4-expression tag
Val 5-expression tag
Glu 6-expression tag
Ser 7-expression tag
Gly 8-expression tag
Gly 9-expression tag
Gly 10-expression tag
Leu 11-expression tag
Val 12-expression tag
Thr 234Pro 447conflict
Tyr 235Phe 448conflict
Glu 236Arg 449conflict
Gln 237Asn 450conflict
Leu 238Met 451conflict
Ser 239Gly 452conflict
Arg 240Met 453conflict
Leu 241Ile 454conflict
Leu 242-expression tag
Thr 243-expression tag
Asn 244-expression tag
Asp 245-expression tag
Asn 246-expression tag
Gly 247-expression tag
Thr 248-expression tag
Asn 249-expression tag
Ser 250-expression tag
Lys 251-expression tag
Thr 252-expression tag
Ser 253-expression tag
Ala 254-expression tag
Gln 255-expression tag
Ala 256-expression tag
Ile 257-expression tag
Asn 258-expression tag
Gln 259-expression tag
Ala 260-expression tag
Val 261-expression tag
Asn 262-expression tag
Asn 263-expression tag
Leu 264-expression tag
Asn 265-expression tag
Glu 266-expression tag
Arg 267-expression tag
Ala 268-expression tag
Lys 269-expression tag
Thr 270-expression tag
Leu 271-expression tag
Ala 272-expression tag
Gly 273-expression tag
Gly 274-expression tag
Thr 275-expression tag
Thr 276-expression tag
Asn 277-expression tag
Ser 278-expression tag
Pro 279-expression tag
Ala 280-expression tag
Tyr 281-expression tag
Gln 282-expression tag
Ala 283-expression tag
Thr 284-expression tag
Leu 285-expression tag
Leu 286-expression tag
Ala 287-expression tag
Leu 288-expression tag
Arg 289-expression tag
Ser 290-expression tag
Val 291-expression tag
Leu 292-expression tag
Gly 293-expression tag
Leu 294-expression tag
Trp 295-expression tag
Asn 296-expression tag
Ser 297-expression tag
Met 298-expression tag
Gly 299-expression tag
Tyr 300-expression tag
Ala 301-expression tag
Val 302-expression tag
Ile 303-expression tag
Cys 304-expression tag
Gly 305-expression tag
Gly 306-expression tag
Tyr 307-expression tag
Thr 308-expression tag
Lys 309-expression tag
Ser 310-expression tag
Pro 311-expression tag
Gly 312-expression tag
Glu 313-expression tag
Asn 314-expression tag
Asn 315-expression tag
Gln 316-expression tag
Lys 317-expression tag
Asp 318-expression tag
Phe 319-expression tag
His 320-expression tag
Tyr 321-expression tag
Thr 322-expression tag
Asp 323-expression tag
Glu 324-expression tag
Asn 325-expression tag
Gly 326-expression tag
Asn 327-expression tag
Gly 328-expression tag
Thr 329-expression tag
Thr 330-expression tag
Ile 331-expression tag
Asn 332-expression tag
Cys 333-expression tag
Gly 334-expression tag
Gly 335-expression tag
Ser 336-expression tag
Thr 337-expression tag
Asn 338-expression tag
Ser 339-expression tag
Asn 340-expression tag
Gly 341-expression tag
Thr 342-expression tag
His 343-expression tag
Ser 344-expression tag
Tyr 345-expression tag
Asn 346-expression tag
Gly 347-expression tag
Thr 348-expression tag
Asn 349-expression tag
Thr 350-expression tag
Leu 351-expression tag
Lys 352-expression tag
Ala 353-expression tag
Asp 354-expression tag
Lys 355-expression tag
Asn 356-expression tag
Val 357-expression tag
Ser 358-expression tag
Leu 359-expression tag
Ser 360-expression tag
Ile 361-expression tag
Glu 362-expression tag
Gln 363-expression tag
Tyr 364-expression tag
Glu 365-expression tag
Lys 366-expression tag
Ile 367-expression tag
His 368-expression tag
Glu 369-expression tag
Ala 370-expression tag
Tyr 371-expression tag
Gln 372-expression tag
Ile 373-expression tag
Leu 374-expression tag
Ser 375-expression tag
Lys 376-expression tag
Ala 377-expression tag
Leu 378-expression tag
Lys 379-expression tag
Gln 380-expression tag
Ala 381-expression tag
Gly 382-expression tag
Leu 383-expression tag
Ala 384-expression tag
Pro 385-expression tag
Leu 386-expression tag
Asn 387-expression tag
Ser 388-expression tag
Lys 389-expression tag
Gly 390-expression tag
Glu 391-expression tag
Lys 392-expression tag
Leu 393-expression tag
Glu 394-expression tag
Ala 395-expression tag
His 396-expression tag
Val 397-expression tag
Thr 398-expression tag
Thr 399-expression tag
Ser 400-expression tag
Lys 401-expression tag
Tyr 402-expression tag
Gly 403-expression tag
Ser 404-expression tag
Leu 405-expression tag
Arg 406-expression tag
Leu 407-expression tag
Ser 408-expression tag
Cys 409-expression tag
Ala 410-expression tag
Ala 411-expression tag
Ser 412-expression tag
Gly 413-expression tag
His 414-expression tag
Thr 415-expression tag
Phe 416-expression tag
Asn 417-expression tag
Tyr 418-expression tag
Pro 419-expression tag
Ile 420-expression tag
Met 421-expression tag
Gly 422-expression tag
Trp 423-expression tag
Phe 424-expression tag
Arg 425-expression tag
Gln 426-expression tag
Ala 427-expression tag
Pro 428-expression tag
Gly 429-expression tag
Lys 430-expression tag
Glu 431-expression tag
Arg 432-expression tag
Glu 433-expression tag
Phe 434-expression tag
Val 435-expression tag
Gly 436-expression tag
Ala 437-expression tag
Ile 438-expression tag
Ser 439-expression tag
Trp 440-expression tag
Ser 441-expression tag
Gly 442-expression tag
Gly 443-expression tag
Ser 444-expression tag
Thr 445-expression tag
Ser 446-expression tag
Tyr 447-expression tag
Ala 448-expression tag
Asp 449-expression tag
Ser 450-expression tag
Val 451-expression tag
Lys 452-expression tag
Asp 453-expression tag
Arg 454-expression tag
Phe 455-expression tag
Thr 456-expression tag
Ile 457-expression tag
Ser 458-expression tag
Arg 459-expression tag
Asp 460-expression tag
Asn 461-expression tag
Ala 462-expression tag
Lys 463-expression tag
Asn 464-expression tag
Thr 465-expression tag
Val 466-expression tag
Tyr 467-expression tag
Leu 468-expression tag
Glu 469-expression tag
Met 470-expression tag
Asn 471-expression tag
Asn 472-expression tag
Leu 473-expression tag
Lys 474-expression tag
Pro 475-expression tag
Glu 476-expression tag
Asp 477-expression tag
Thr 478-expression tag
Ala 479-expression tag
Val 480-expression tag
Tyr 481-expression tag
Tyr 482-expression tag
Cys 483-expression tag
Ala 484-expression tag
Ala 485-expression tag
Lys 486-expression tag
Gly 487-expression tag
Arg 488-expression tag
Tyr 489-expression tag
Ser 490-expression tag
Gly 491-expression tag
Gly 492-expression tag
Leu 493-expression tag
Tyr 494-expression tag
Tyr 495-expression tag
Pro 496-expression tag
Thr 497-expression tag
Asn 498-expression tag
Tyr 499-expression tag
Asp 500-expression tag
Tyr 501-expression tag
Trp 502-expression tag
Gly 503-expression tag
Gln 504-expression tag
Gly 505-expression tag
Thr 506-expression tag
Gln 507-expression tag
Val 508-expression tag
Thr 509-expression tag
Val 510-expression tag
Ser 511-expression tag
Ser 512-expression tag
His 513-expression tag
His 514-expression tag
His 515-expression tag
His 516-expression tag
His 517-expression tag
His 518-expression tag
Glu 519-expression tag
Pro 520-expression tag
Glu 521-expression tag
Ala 522-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains6
Total formula weight423910.0
BranchedNumber of molecules9
Total formula weight6413.9
Non-Polymers*Number of molecules4
Total formula weight665.8
All*Total formula weight430989.6
*Water molecules are not included.

250835

PDB entries from 2026-03-18

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