9RHU
Rabbit 80S ribosome in complex with eRF1-AAQ, stalled at the Stop codon in mutated F2A sequence
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (MB) | 60S ribosomal protein L34 | polymer | 117 | 13326.1 | 1 | UniProt (G1TXG5) | Oryctolagus cuniculus (rabbit) | |
| 2 | B (A1) | 18S rRNA | polymer | 1870 | 603928.3 | 1 | Oryctolagus cuniculus | ||
| 3 | C (A2) | 60S ribosomal protein L6 | polymer | 291 | 33028.3 | 1 | UniProt (G1SKF7) | Oryctolagus cuniculus (rabbit) | |
| 4 | D (A3) | 28S rRNA | polymer | 4808 | 1557519.5 | 1 | GenBank (GBCN01009604.1) | Oryctolagus cuniculus (rabbit) | |
| 5 | E (B1) | Small ribosomal subunit protein eS27 | polymer | 84 | 9480.2 | 1 | UniProt (G1TZ76) | Oryctolagus cuniculus (rabbit) | |
| 6 | F (B2) | 60S ribosomal protein L7 | polymer | 249 | 29514.3 | 1 | UniProt (G1SV32) | Oryctolagus cuniculus (rabbit) | uL30 |
| 7 | G (B3) | 5S rRNA | polymer | 119 | 38346.7 | 1 | GenBank (GBCM01014045.1) | Oryctolagus cuniculus (rabbit) | |
| 8 | H (C1) | Small ribosomal subunit protein eS28 | polymer | 69 | 7855.1 | 1 | UniProt (G1TIB4) | Oryctolagus cuniculus (rabbit) | |
| 9 | I (C2) | Large ribosomal subunit protein eL8 | polymer | 319 | 36193.5 | 1 | UniProt (G1STW0) | Oryctolagus cuniculus (rabbit) | 60S ribosomal protein L7a |
| 10 | J (C3) | 5.8S rRNA | polymer | 158 | 50809.0 | 1 | GenBank (GBCN01009604.1) | Oryctolagus cuniculus (rabbit) | |
| 11 | K (D1) | Ubiquitin-ribosomal protein eS31 fusion protein | polymer | 80 | 9445.2 | 1 | UniProt (G1SK22) | Oryctolagus cuniculus (rabbit) | |
| 12 | L (D2) | 60S ribosomal protein L9 | polymer | 192 | 21871.4 | 1 | UniProt (G1SWI6) | Oryctolagus cuniculus (rabbit) | |
| 13 | M (D3) | Large ribosomal subunit protein uL2 | polymer | 257 | 28103.9 | 1 | UniProt (G1TT27) | Oryctolagus cuniculus (rabbit) | 60S ribosomal protein L8 |
| 14 | N (E1) | 40S ribosomal protein eS30 | polymer | 59 | 6741.0 | 1 | UniProt (G1T8A2) | Oryctolagus cuniculus (rabbit) | |
| 15 | O (E2) | 60S ribosomal protein L10 | polymer | 214 | 24643.1 | 1 | UniProt (B7NZQ2) | Oryctolagus cuniculus (rabbit) | Ribosomal protein L10 |
| 16 | P (E3) | Ribosomal protein L3 | polymer | 403 | 46121.0 | 1 | UniProt (G1TL06) | Oryctolagus cuniculus (rabbit) | |
| 17 | Q (F1) | eS26 | polymer | 115 | 13047.5 | 1 | UniProt (A0A2K5LQY6) | Oryctolagus cuniculus (rabbit) | |
| 18 | R (F2) | 60S ribosomal protein L11 | polymer | 178 | 20288.5 | 1 | UniProt (G1TUB8) | Oryctolagus cuniculus (rabbit) | |
| 19 | S (F3) | Large ribosomal subunit protein uL4 | polymer | 413 | 46283.7 | 1 | UniProt (G1SVW5) | Oryctolagus cuniculus (rabbit) | 60S ribosomal protein L4 |
| 20 | T (G1) | Small ribosomal subunit protein RACK1 | polymer | 317 | 35115.7 | 1 | UniProt (G1SJB4) | Oryctolagus cuniculus (rabbit) | RACK1 |
| 21 | U (G2) | Choriogonadotropin subunit beta variant 1,Genome polyprotein,Genome polyprotein | polymer | 184 | 20020.9 | 1 | UniProt (Q9Q2N9) | Homo sapiens (human) | |
| 22 | V (G3) | Large ribosomal subunit protein uL18 | polymer | 296 | 34424.8 | 1 | UniProt (P19949) | Oryctolagus cuniculus (rabbit) | 60S ribosomal protein L5 |
| 23 | W (H1) | Small ribosomal subunit protein uS14 | polymer | 56 | 6690.8 | 1 | UniProt (G1U7M4) | Oryctolagus cuniculus (rabbit) | uS14 |
| 24 | X (H2) | Large ribosomal subunit protein eL13 | polymer | 211 | 24331.7 | 1 | UniProt (G1TKB3) | Oryctolagus cuniculus (rabbit) | 60S ribosomal protein L13 |
| 25 | Y (I1) | mRNA containing F2A sequence | polymer | 659 | 211439.7 | 1 | Foot-and-mouth disease virus SAT 2 | ||
| 26 | Z (I2) | 60S ribosomal protein L14 | polymer | 218 | 23870.5 | 1 | UniProt (G1SZ12) | Oryctolagus cuniculus (rabbit) | |
| 27 | AA (J1) | E-site tRNA-Pro | polymer | 75 | 24102.3 | 1 | Oryctolagus cuniculus | ||
| 28 | BA (J2) | Ribosomal protein L15 | polymer | 204 | 24207.3 | 1 | UniProt (G1T0C1) | Oryctolagus cuniculus (rabbit) | |
| 29 | CA (K1) | P-site tRNA-Gly | polymer | 74 | 23896.3 | 1 | Oryctolagus cuniculus | ||
| 30 | DA (K2) | Large ribosomal subunit protein uL13 | polymer | 203 | 23533.3 | 1 | UniProt (G1TVS8) | Oryctolagus cuniculus (rabbit) | 60S ribosomal protein L13a |
| 31 | EA (L1) | Small ribosomal subunit protein uS2 | polymer | 295 | 32822.8 | 1 | UniProt (G1TLT8) | Oryctolagus cuniculus (rabbit) | 37 kDa laminin receptor precursor,37LRP,37/67 kDa laminin receptor,LRP/LR,67 kDa laminin receptor,67LR,Laminin receptor 1,LamR,Laminin-binding protein precursor p40,LBP/p40 |
| 32 | FA (L2) | Large ribosomal subunit protein uL22 | polymer | 184 | 21444.2 | 1 | UniProt (G1SCJ6) | Oryctolagus cuniculus (rabbit) | 60S ribosomal protein L17 |
| 33 | GA (M1) | 40S ribosomal protein S3a | polymer | 264 | 30002.1 | 1 | UniProt (G1SS70) | Oryctolagus cuniculus (rabbit) | RPS3A |
| 34 | HA (M2) | eL18 | polymer | 188 | 21699.7 | 1 | UniProt (F6QKI9) | Oryctolagus cuniculus (rabbit) | |
| 35 | IA (N1) | 40S ribosomal protein S2 | polymer | 293 | 31285.4 | 1 | UniProt (O18789) | Oryctolagus cuniculus (rabbit) | |
| 36 | JA (N2) | Ribosomal protein L19 | polymer | 196 | 23535.3 | 1 | UniProt (G1TYL6) | Oryctolagus cuniculus (rabbit) | |
| 37 | KA (O1) | Small ribosomal subunit protein uS3 | polymer | 243 | 26715.3 | 1 | UniProt (G1TNM3) | Oryctolagus cuniculus (rabbit) | |
| 38 | LA (O2) | Large ribosomal subunit protein eL20 | polymer | 176 | 20749.4 | 1 | UniProt (G1TTY7) | Oryctolagus cuniculus (rabbit) | 60S ribosomal protein L18a |
| 39 | MA (P1) | 40S ribosomal protein S4 | polymer | 263 | 29654.9 | 1 | UniProt (G1TK17) | Oryctolagus cuniculus (rabbit) | |
| 40 | NA (P2) | 60S ribosomal protein L21 | polymer | 160 | 18610.0 | 1 | UniProt (G1SHQ2) | Oryctolagus cuniculus (rabbit) | eL21 |
| 41 | OA (Q1) | Small ribosomal subunit protein uS7 | polymer | 204 | 22913.5 | 1 | UniProt (G1TFM5) | Oryctolagus cuniculus (rabbit) | |
| 42 | PA (Q2) | 60S ribosomal protein L22 | polymer | 128 | 14756.9 | 1 | UniProt (G1TSG1) | Oryctolagus cuniculus (rabbit) | |
| 43 | QA (R1) | 40S ribosomal protein S6 | polymer | 249 | 28751.9 | 1 | UniProt (G1TM55) | Oryctolagus cuniculus (rabbit) | |
| 44 | RA (R2) | Ribosomal protein L23 | polymer | 140 | 14892.5 | 1 | UniProt (G1T6D1) | Oryctolagus cuniculus (rabbit) | |
| 45 | SA (S1) | Small ribosomal subunit protein eS7 | polymer | 194 | 22168.9 | 1 | UniProt (G1SVB0) | Oryctolagus cuniculus (rabbit) | |
| 46 | TA (S2) | Ribosomal protein L24 | polymer | 157 | 17825.1 | 1 | UniProt (G1SE28) | Oryctolagus cuniculus (rabbit) | eL24 |
| 47 | UA (T1) | 40S ribosomal protein S8 | polymer | 208 | 24263.4 | 1 | UniProt (G1TJW1) | Oryctolagus cuniculus (rabbit) | |
| 48 | VA (T2) | Large ribosomal subunit protein uL23 | polymer | 156 | 17768.2 | 1 | UniProt (G1SE76) | Oryctolagus cuniculus (rabbit) | uL23 |
| 49 | WA (U1) | Small ribosomal subunit protein uS4 | polymer | 194 | 22641.6 | 1 | UniProt (B7NZS8) | Oryctolagus cuniculus (rabbit) | |
| 50 | XA (U2) | Ribosomal protein L26 | polymer | 145 | 17303.4 | 1 | UniProt (G1SQH0) | Oryctolagus cuniculus (rabbit) | |
| 51 | YA (V1) | eS10 | polymer | 165 | 18933.8 | 1 | UniProt (G1T168) | Oryctolagus cuniculus (rabbit) | |
| 52 | ZA (V2) | 60S ribosomal protein L27 | polymer | 136 | 15835.8 | 1 | UniProt (G1TXF6) | Oryctolagus cuniculus (rabbit) | |
| 53 | AB (W1) | Small ribosomal subunit protein uS17 | polymer | 158 | 18468.8 | 1 | UniProt (G1TRM4) | Oryctolagus cuniculus (rabbit) | |
| 54 | BB (W2) | 60S ribosomal protein L27a | polymer | 148 | 16635.6 | 1 | UniProt (G1SNY0) | Oryctolagus cuniculus (rabbit) | |
| 55 | CB (X1) | Small ribosomal subunit protein eS12 | polymer | 132 | 14539.0 | 1 | UniProt (G1SFR8) | Oryctolagus cuniculus (rabbit) | |
| 56 | DB (X2) | 60S ribosomal protein L29 | polymer | 245 | 26721.7 | 1 | UniProt (G1SGR6) | Oryctolagus cuniculus (rabbit) | |
| 57 | EB (Y1) | Small ribosomal subunit protein uS15 | polymer | 151 | 17259.4 | 1 | UniProt (G1SP51) | Oryctolagus cuniculus (rabbit) | uS15 |
| 58 | FB (Y2) | 60S ribosomal protein L30 | polymer | 115 | 12807.1 | 1 | UniProt (G1TDL2) | Oryctolagus cuniculus (rabbit) | eL30 |
| 59 | GB (Z1) | Small ribosomal subunit protein uS11 | polymer | 151 | 16302.8 | 1 | UniProt (G1T1F0) | Oryctolagus cuniculus (rabbit) | |
| 60 | HB (Z2) | 60S ribosomal protein L31 | polymer | 125 | 14494.9 | 1 | UniProt (G1SHG0) | Oryctolagus cuniculus (rabbit) | eL31 |
| 61 | IB (a1) | Small ribosomal subunit protein uS19 | polymer | 145 | 17049.2 | 1 | UniProt (G1U0Q2) | Oryctolagus cuniculus (rabbit) | |
| 62 | JB (a2) | Ribosomal protein L32 | polymer | 135 | 15898.9 | 1 | UniProt (A0AAA9WVN6) | Oryctolagus cuniculus (rabbit) | |
| 63 | KB (b1) | Small ribosomal subunit protein uS9 | polymer | 146 | 16477.4 | 1 | UniProt (G1SGX4) | Oryctolagus cuniculus (rabbit) | |
| 64 | LB (b2) | 60S ribosomal protein L35a | polymer | 110 | 12580.8 | 1 | UniProt (G1SF08) | Oryctolagus cuniculus (rabbit) | eL33 |
| 65 | MB (c1) | Small ribosomal subunit protein eS17 | polymer | 135 | 15552.1 | 1 | UniProt (G1TU13) | Oryctolagus cuniculus (rabbit) | |
| 66 | NB (d1) | Small ribosomal subunit protein uS13 | polymer | 152 | 17654.6 | 1 | UniProt (G1TPG3) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S18 |
| 67 | OB (d2) | 60S ribosomal protein L35 | polymer | 123 | 14566.6 | 1 | UniProt (G1SIT5) | Oryctolagus cuniculus (rabbit) | uL29 |
| 68 | PB (e1) | 40S ribosomal protein eS19 | polymer | 144 | 15966.4 | 1 | UniProt (A0ABF7PQ95) | Oryctolagus cuniculus (rabbit) | |
| 69 | QB (e2) | Large ribosomal subunit protein eL36 | polymer | 105 | 12263.8 | 1 | UniProt (G1TTQ5) | Oryctolagus cuniculus (rabbit) | 60S ribosomal protein L36 |
| 70 | RB (f1) | Small ribosomal subunit protein uS10 | polymer | 119 | 13398.8 | 1 | UniProt (G1SIZ2) | Oryctolagus cuniculus (rabbit) | |
| 71 | SB (f2) | Ribosomal protein L37 | polymer | 97 | 11111.0 | 1 | UniProt (U3KPD5) | Oryctolagus cuniculus (rabbit) | |
| 72 | TB (g1) | Small ribosomal subunit protein eS21 | polymer | 84 | 9165.4 | 1 | UniProt (G1TM82) | Oryctolagus cuniculus (rabbit) | 40S ribosomal protein S21 |
| 73 | UB (g2) | 60S ribosomal protein L38 | polymer | 70 | 8238.9 | 1 | UniProt (G1U001) | Oryctolagus cuniculus (rabbit) | eL38 |
| 74 | VB (h1) | Small ribosomal subunit protein uS8 | polymer | 130 | 14865.6 | 1 | UniProt (G1TG89) | Oryctolagus cuniculus (rabbit) | |
| 75 | WB (h2) | 60S ribosomal protein L39-like | polymer | 51 | 6455.8 | 1 | UniProt (G1TTN1) | Oryctolagus cuniculus (rabbit) | eL39 |
| 76 | XB (i1) | 40S ribosomal protein S23 | polymer | 143 | 15860.7 | 1 | UniProt (G1SZ47) | Oryctolagus cuniculus (rabbit) | |
| 77 | YB (i2) | Ubiquitin-ribosomal protein eL40 fusion protein | polymer | 52 | 6241.7 | 1 | UniProt (P0DXC2) | Oryctolagus cuniculus (rabbit) | Ubiquitin A-52 residue ribosomal protein fusion product 1 |
| 78 | ZB (j1) | 40S ribosomal protein S24 | polymer | 133 | 15463.3 | 1 | UniProt (A0A5F9D2E6) | Oryctolagus cuniculus (rabbit) | |
| 79 | AC (j2) | Ribosomal protein L36a | polymer | 141 | 16143.2 | 1 | UniProt (A0A5F9D391) | Oryctolagus cuniculus (rabbit) | |
| 80 | BC (k1) | Small ribosomal subunit protein eS25 | polymer | 124 | 13645.0 | 1 | UniProt (G1TDB3) | Oryctolagus cuniculus (rabbit) | |
| 81 | CC (k2) | 60S ribosomal protein L37a | polymer | 92 | 10299.4 | 1 | UniProt (G1SY53) | Oryctolagus cuniculus (rabbit) | eL43 |
| 82 | DC (l1) | Small ribosomal subunit protein eS32 | polymer | 25 | 3473.5 | 1 | UniProt (A0A087WNH4) | Oryctolagus cuniculus (rabbit) | |
| 83 | EC (l2) | [histone H4]-N-methyl-L-lysine20 N-methyltransferase KMT5B | polymer | 137 | 15697.5 | 1 | UniProt (A0A8C0DF35) | Oryctolagus cuniculus (rabbit) | [histone H4]-lysine20 N-methyltransferase KMT5B |
| 84 | FC (m2) | Large ribosomal subunit protein uL10 | polymer | 318 | 34380.5 | 1 | UniProt (G1SPK4) | Oryctolagus cuniculus (rabbit) | uL10 |
| 85 | GC (n2) | 60S ribosomal protein L12 | polymer | 165 | 17847.6 | 1 | UniProt (G1SMR7) | Oryctolagus cuniculus (rabbit) | |
| 86 | HC (o2) | Ribosomal protein uL1 | polymer | 217 | 24875.4 | 1 | UniProt (G1SKZ8) | Oryctolagus cuniculus (rabbit) | |
| 87 | IC (p2) | Eukaryotic peptide chain release factor subunit 1 | polymer | 438 | 49143.8 | 1 | UniProt (P62495) | Homo sapiens (human) | Eukaryotic release factor 1,eRF1,Protein Cl1,TB3-1 |
| 88 | JC (q2) | ATP binding cassette subfamily E member 1 | polymer | 599 | 67405.2 | 1 | UniProt (G1SG72) | Oryctolagus cuniculus (rabbit) | |
| 89 | AD, AE, AF, AG, AH... (A1, A3, L2, R2, i1...) | MAGNESIUM ION | non-polymer | 24.3 | 367 | Chemie (MG) | |||
| 90 | ES, GS, HS, IS, LC... (f2, i2, j2, k2, MB...) | ZINC ION | non-polymer | 65.4 | 8 | Chemie (ZN) | |||
| 91 | AJ, BD, BJ, CD, CR... (A3, A1, O2, B3, C3...) | POTASSIUM ION | non-polymer | 39.1 | 37 | Chemie (K) | |||
| 92 | AR, ZQ (A3) | SPERMIDINE | non-polymer | 145.2 | 2 | Chemie (SPD) | |||
| 93 | DR (B3) | GUANOSINE-5'-TRIPHOSPHATE | non-polymer | 523.2 | 1 | Chemie (GTP) | |||
| 94 | JS, KS (q2) | IRON/SULFUR CLUSTER | non-polymer | 351.6 | 2 | Chemie (SF4) |
Sequence modifications
A3: 1 - 4808 (GenBank: GBCN01009604.1)
C2: -52 - 266 (UniProt: G1STW0)
F3: 2 - 413 (UniProt: G1SVW5)
G2: -165 - -32 (PDB: 9RHU)
G2: -31 - 18 (UniProt: Q9Q2N9)
G3: 3 - 297 (UniProt: P19949)
H2: 1 - 211 (UniProt: G1TKB3)
L1: 2 - 295 (UniProt: G1TLT8)
M2: 1 - 188 (UniProt: F6QKI9)
N1: 1 - 293 (UniProt: O18789)
N2: 1 - 196 (UniProt: G1TYL6)
P1: 1 - 263 (UniProt: G1TK17)
Q2: 1 - 128 (UniProt: G1TSG1)
T1: 1 - 208 (UniProt: G1TJW1)
d1: 2 - 152 (UniProt: G1TPG3)
e2: 1 - 105 (UniProt: G1TTQ5)
g1: 1 - 83 (UniProt: G1TM82)
g2: 1 - 70 (UniProt: G1U001)
l2: 2 - 137 (UniProt: A0A8C0DF35)
p2: 2 - 437 (UniProt: P62495)
| PDB | External Database | Details |
|---|---|---|
| Uy1 3550 | U 5943 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ala 86 | Val 139 | conflict |
| Gly 191 | Cys 244 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ace 2 | - | acetylation |
G2: -31 - 18 (UniProt: Q9Q2N9)
G3: 3 - 297 (UniProt: P19949)
| PDB | External Database | Details |
|---|---|---|
| Met 2 | - | initiating methionine |
| PDB | External Database | Details |
|---|---|---|
| Arg 74 | His 74 | conflict |
| Arg 190 | His 190 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ace 1 | - | acetylation |
| PDB | External Database | Details |
|---|---|---|
| Arg 134 | Cys 134 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ile 33 | Val 33 | conflict |
| Ala 101 | Ser 101 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 38 | His 38 | conflict |
| Arg 151 | His 151 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 25 | Ser 25 | conflict |
| Arg 51 | Lys 51 | conflict |
| Thr 78 | Ala 78 | conflict |
| Val 156 | Met 156 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Gly 32 | Arg 32 | conflict |
| Ala 36 | Glu 36 | conflict |
| Phe 39 | Ser 39 | conflict |
| Gly 54 | Arg 54 | conflict |
| Arg 97 | His 97 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 47 | Gly 47 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ace 1 | - | acetylation |
| PDB | External Database | Details |
|---|---|---|
| Gly 31 | Arg 31 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ace 0 | - | acetylation |
| PDB | External Database | Details |
|---|---|---|
| Lys 24 | Asn 24 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ace 1 | - | acetylation |
| PDB | External Database | Details |
|---|---|---|
| Gly 0 | - | expression tag |
| Pro 1 | - | expression tag |
| Ala 183 | Gly 183 | engineered mutation |
| Ala 184 | Gly 184 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 88 |
| Total formula weight | 4171704.9 | |
| Non-Polymers* | Number of molecules | 417 |
| Total formula weight | 12406.8 | |
| All* | Total formula weight | 4184111.7 |
