9RG8

Crystal structure of DNPH1 bound by compound 1.

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	5-hydroxymethyl-dUMP N-hydrolase	polymer	152	17174.3	2	UniProt (O43598) Pfam (PF05014)	Homo sapiens (human)	2'-deoxynucleoside 5'-phosphate N-hydrolase 1,c-Myc-responsive protein RCL
2	C (A)	2-[1-methyl-5-[[1-[3-(pyrimidin-2-ylamino)phenyl]carbonylpiperidin-4-yl]amino]-1,2,4-triazol-3-yl]-1~{H}-indole-6-carbonitrile	non-polymer		518.6	1	Chemie (A1JFX)
3	D, E (A, B)	water	water		18.0	53	Chemie (HOH)

Sequence modifications

A, B: 20 - 162 (UniProt: O43598)

PDB	External Database	Details
Met 19	-	initiating methionine
Leu 163	-	expression tag
Glu 164	-	expression tag
Glu 165	-	expression tag
Asn 166	-	expression tag
Leu 167	-	expression tag
Tyr 168	-	expression tag
Phe 169	-	expression tag
Gln 170	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	34348.6
Non-Polymers*	Number of molecules	1
	Total formula weight	518.6
All*	Total formula weight	34867.2

*Water molecules are not included.