9RCV
Structure of the Human Peptide-Loading Complex Arrested by HCMV US6
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Antigen peptide transporter 1 | polymer | 748 | 81080.4 | 1 | UniProt (Q03518) Pfam (PF00664) Pfam (PF00005) | Homo sapiens (human) | APT1,ATP-binding cassette sub-family B member 2,Peptide supply factor 1,Peptide transporter PSF1,PSF-1,Peptide transporter TAP1,Peptide transporter involved in antigen processing 1,Really interesting new gene 4 protein,RING4 |
| 2 | B, F (B, F) | Tapasin | polymer | 448 | 47673.5 | 2 | UniProt (O15533) Pfam (PF07654) | Homo sapiens (human) | TPN,TPSN,NGS-17,TAP-associated protein,TAP-binding protein |
| 3 | C, G (C, G) | MHC class I antigen | polymer | 362 | 40481.0 | 2 | UniProt (A0A678ZHF8) | Homo sapiens (human) | |
| 4 | D, H (D, H) | Beta-2-microglobulin | polymer | 119 | 13732.5 | 2 | UniProt (P61769) Pfam (PF07654) | Homo sapiens (human) | |
| 5 | E (E) | Antigen peptide transporter 2 | polymer | 677 | 74697.2 | 1 | UniProt (Q03519) Pfam (PF00664) Pfam (PF00005) | Homo sapiens (human) | APT2,ATP-binding cassette sub-family B member 3,Peptide supply factor 2,Peptide transporter PSF2,PSF-2,Peptide transporter TAP2,Peptide transporter involved in antigen processing 2,Really interesting new gene 11 protein,RING11 |
| 6 | I (I) | Unique short US6 glycoprotein | polymer | 183 | 20671.1 | 1 | UniProt (P14334) Pfam (PF17616) | Homo sapiens (human) | Protein HXLF6,gpUS6 |
| 7 | J, K (J, K) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 8 | L (A) | ADENOSINE-5'-TRIPHOSPHATE | non-polymer | 507.2 | 1 | Chemie (ATP) | |||
| 9 | M, P (A, E) | MAGNESIUM ION | non-polymer | 24.3 | 2 | Chemie (MG) | |||
| 10 | N, Q (C, G) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 11 | O (E) | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 1 | Chemie (ADP) | |||
| 12 | R, S (A, E) | water | water | 18.0 | 4 | Chemie (HOH) |
Sequence modifications
A: 1 - 748 (UniProt: Q03518)
B, F: -19 - 428 (UniProt: O15533)
| PDB | External Database | Details |
|---|---|---|
| Cys 419 | Gly 419 | variant |
| PDB | External Database | Details |
|---|---|---|
| Arg 240 | Thr 260 | variant |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 9 |
| Total formula weight | 380222.9 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1425.4 | |
| All* | Total formula weight | 382497.1 |
