9R9M
Crystal Structure of human MLH1 C-terminal domain with cyclic peptide (2S)-N-[(6S,9S,12S,15S,18S,26aR)-12-(4-aminobutyl)-18-benzyl-21-(2-carbamoylethyl)-9-(hydroxymethyl)- 15-[(4-hydroxyphenyl)methyl]-1,7,10,13,16,19,22-heptaoxo-hexacosahydropyrrolo[2,1-c]1,4,7,10,13,16,19-heptaazacyclotetracosan-6-yl]-2-[(2S)-2-acetamidopropanamido]-3-methylbutanamide
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | DNA mismatch repair protein Mlh1 | polymer | 267 | 30607.8 | 2 | UniProt (P40692) | Homo sapiens (human) | MutL protein homolog 1 |
| 2 | C (I) | Cyclic peptide 1 | polymer | 10 | 1080.3 | 1 | synthetic construct | ||
| 3 | D (C) | Cyclic peptide 2 | polymer | 9 | 1028.2 | 1 | synthetic construct | ||
| 4 | E, F, G, H, I... (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 10 | Chemie (EDO) | |||
| 5 | L, M, N, O, U... (A, B) | CALCIUM ION | non-polymer | 40.1 | 6 | Chemie (CA) PubChem (271) | |||
| 6 | P, R, S (B) | ACETATE ION | non-polymer | 59.0 | 3 | Chemie (ACT) PubChem (175) | |||
| 7 | AA, X, Y, Z (C, A, B, I) | water | water | 18.0 | 190 | Chemie (HOH) |
Sequence modifications
A, B: 486 - 751 (UniProt: P40692)
| PDB | External Database | Details |
|---|---|---|
| Gly 485 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 63324.1 | |
| Non-Polymers* | Number of molecules | 19 |
| Total formula weight | 1038.3 | |
| All* | Total formula weight | 64362.4 |
