9R8Z

METTL3/14 complex with switchable fragment

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	N(6)-adenosine-methyltransferase catalytic subunit METTL3	polymer	224	25604.4	1	UniProt (Q86U44) Pfam (PF05063)	Homo sapiens (human)	Methyltransferase-like protein 3,hMETTL3,N(6)-adenosine-methyltransferase 70 kDa subunit,MT-A70
2	B (B)	N(6)-adenosine-methyltransferase non-catalytic subunit METTL14	polymer	348	39516.6	1	UniProt (Q9HCE5) Pfam (PF05063)	Homo sapiens (human)	Methyltransferase-like protein 14,hMETTL14
3	C, D, H, I, J (A, B)	DIMETHYL SULFOXIDE	non-polymer		78.1	5	Chemie (DMS) PubChem (679)
4	E (A)	1-(1~{H}-imidazol-2-yl)-2-phenyl-diazane	non-polymer		174.2	1	Chemie (A1JDK)
5	F, G (A)	CHLORIDE ION	non-polymer		35.5	2	Chemie (CL) PubChem (312)
6	K, L (A, B)	water	water		18.0	228	Chemie (HOH)

Sequence modifications

A: 358 - 580 (UniProt: Q86U44)

PDB	External Database	Details
Met 357	-	initiating methionine

B: 111 - 456 (UniProt: Q9HCE5)

PDB	External Database	Details
Gly 109	-	expression tag
Ser 110	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	65121.0
Non-Polymers*	Number of molecules	8
	Total formula weight	635.8
All*	Total formula weight	65756.8

*Water molecules are not included.