9R8C
CRYSTAL STRUCTURE OF WILD-TYPE PLK1 KINASE DOMAIN IN COMPLEX WITH THIAZOLIDINONE INHIBITOR COMPOUND 1 AND A SELECTIVE DARPIN
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase PLK1 | polymer | 315 | 35972.9 | 2 | UniProt (P53350) Pfam (PF00069) | Homo sapiens (human) | Polo-like kinase 1,PLK-1,Serine/threonine-protein kinase 13,STPK13 |
| 2 | C, D (C, D) | DESIGNED ANKYRIN REPEAT PROTEIN 3H10 | polymer | 167 | 17836.0 | 2 | Homo sapiens | ||
| 3 | E, H (A, B) | 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide | non-polymer | 521.7 | 2 | Chemie (R78) | |||
| 4 | F, G, I, J (A, B, D) | GLYCEROL | non-polymer | 92.1 | 4 | Chemie (GOL) | |||
| 5 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 329 | Chemie (HOH) |
Sequence modifications
A, B: 33 - 345 (UniProt: P53350)
| PDB | External Database | Details |
|---|---|---|
| Gly 31 | - | expression tag |
| Ser 32 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 107617.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1411.7 | |
| All* | Total formula weight | 109029.4 |
