9R59
Crystal structure of MAPKAPK2 with a covalent compound GCL334 targeting lysine
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | MAP kinase-activated protein kinase 2 | polymer | 320 | 36903.7 | 1 | UniProt (P49137) Pfam (PF00069) | Homo sapiens (human) | MAPK-activated protein kinase 2,MAPKAP kinase 2,MAPKAP-K2,MAPKAPK-2,MK-2,MK2 |
| 2 | B (A) | 5-[3-[bis(oxidanyl)-$l^{3}-sulfanyl]oxy-4-chloranyl-phenyl]-~{N}-(4-piperazin-1-ylphenyl)-~{N}-(pyridin-2-ylmethyl)furan-2-carboxamide | non-polymer | 571.0 | 1 | Chemie (A1JH4) | Homo sapiens | ||
| 3 | C (A) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A: 48 - 364 (UniProt: P49137)
| PDB | External Database | Details |
|---|---|---|
| Gly 45 | - | expression tag |
| His 46 | - | expression tag |
| Met 47 | - | expression tag |
| Gly 216 | Ser 216 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 36903.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 571.0 | |
| All* | Total formula weight | 37474.7 |
