9R1Y
PLK1 SURFACE ENTROPY REDUCTION (SER) MUTANT IN COMPLEX WITH INHIBITOR GSK461364
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (AAA, BBB) | Serine/threonine-protein kinase PLK1 | polymer | 325 | 36546.4 | 2 | UniProt (P53350) Pfam (PF00069) | Homo sapiens (human) | Polo-like kinase 1,PLK-1,Serine/threonine-protein kinase 13,STPK13 |
| 2 | C, O (AAA, BBB) | 5-[6-[(4-methylpiperazin-1-yl)methyl]benzimidazol-1-yl]-3-[(1~{R})-1-[2-(trifluoromethyl)phenyl]ethoxy]thiophene-2-carboxamide | non-polymer | 543.6 | 2 | Chemie (A1JCQ) | |||
| 3 | D, E, F, G, H... (AAA, BBB) | SULFATE ION | non-polymer | 96.1 | 8 | Chemie (SO4) | |||
| 4 | J (AAA) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 5 | K, L, M, N, R (AAA, BBB) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 6 | S, T (AAA, BBB) | water | water | 18.0 | 56 | Chemie (HOH) |
Sequence modifications
AAA, BBB: 18 - 340 (UniProt: P53350)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
| Ser 17 | - | expression tag |
| Asp 225 | Lys 225 | engineered mutation |
| Ala 226 | Lys 226 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73092.8 | |
| Non-Polymers* | Number of molecules | 16 |
| Total formula weight | 2351.6 | |
| All* | Total formula weight | 75444.4 |
