9R1W
PLK1 SURFACE ENTROPY REDUCTION (SER) MUTANT IN COMPLEX WITH THIAZOLIDINONE INHIBITOR COMPOUND 1
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (AAA, BBB) | Serine/threonine-protein kinase PLK1 | polymer | 325 | 36546.4 | 2 | UniProt (P53350) Pfam (PF00069) | Homo sapiens (human) | Polo-like kinase 1,PLK-1,Serine/threonine-protein kinase 13,STPK13 |
| 2 | C, L (AAA, BBB) | (2~{Z})-2-cyano-2-[3-ethyl-5-[(~{E})-[2-[methyl-(1-methylpiperidin-4-yl)amino]pyridin-4-yl]iminomethyl]-4-oxidanylidene-1,3-thiazol-2-ylidene]-~{N}-[2,2,2-tris(fluoranyl)ethyl]ethanamide | non-polymer | 523.6 | 2 | Chemie (A1JCP) | |||
| 3 | D, E, I, J, M... (AAA, BBB) | SULFATE ION | non-polymer | 96.1 | 6 | Chemie (SO4) | |||
| 4 | F, G, K, N, P (AAA, BBB) | GLYCEROL | non-polymer | 92.1 | 5 | Chemie (GOL) | |||
| 5 | H (AAA) | CHLORIDE ION | non-polymer | 35.5 | 1 | Chemie (CL) | |||
| 6 | Q, R (AAA, BBB) | water | water | 18.0 | 185 | Chemie (HOH) |
Sequence modifications
AAA, BBB: 18 - 340 (UniProt: P53350)
| PDB | External Database | Details |
|---|---|---|
| Gly 16 | - | expression tag |
| Ser 17 | - | expression tag |
| Asp 225 | Lys 225 | engineered mutation |
| Ala 226 | Lys 226 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 73092.8 | |
| Non-Polymers* | Number of molecules | 14 |
| Total formula weight | 2119.4 | |
| All* | Total formula weight | 75212.2 |
