9R16

Structure of mutant SHP2

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Tyrosine-protein phosphatase non-receptor type 11	polymer	536	61713.6	2	UniProt (Q06124) Pfam (PF00017) Pfam (PF00102)	Homo sapiens (human)	Protein-tyrosine phosphatase 1D,PTP-1D,Protein-tyrosine phosphatase 2C,PTP-2C,SH-PTP2,SHP-2,Shp2,SH-PTP3
2	C, D (A, B)	water	water		18.0	252	Chemie (HOH)

Sequence modifications

A, B: 1 - 528 (UniProt: Q06124)

PDB	External Database	Details
Asp 62	Tyr 62	engineered mutation
Leu 529	-	expression tag
Glu 530	-	expression tag
His 531	-	expression tag
His 532	-	expression tag
His 533	-	expression tag
His 534	-	expression tag
His 535	-	expression tag
His 536	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	123427.1
All*	Total formula weight	123427.1

*Water molecules are not included.