9R0E
Structure of the human heterotetrameric cis-prenyltransferase complex harboring NgBR-S249T in complex with magnesium, FsPP and IPP
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Dehydrodolichyl diphosphate synthase complex subunit DHDDS | polymer | 340 | 39202.0 | 1 | UniProt (Q86SQ9) | Homo sapiens (human) | Cis-isoprenyltransferase,Cis-IPTase,Cis-prenyltransferase subunit hCIT,Epididymis tissue protein Li 189m |
| 2 | B (B) | Dehydrodolichyl diphosphate synthase complex subunit NUS1 | polymer | 213 | 23793.2 | 1 | UniProt (Q96E22) | Homo sapiens (human) | Cis-prenyltransferase subunit NgBR,Nogo-B receptor,NgBR,Nuclear undecaprenyl pyrophosphate synthase 1 homolog |
| 3 | C (A) | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE | non-polymer | 246.1 | 1 | Chemie (IPE) | |||
| 4 | D (A) | S-[(2E,6E)-3,7,11-TRIMETHYLDODECA-2,6,10-TRIENYL] TRIHYDROGEN THIODIPHOSPHATE | non-polymer | 398.4 | 1 | Chemie (FPS) | |||
| 5 | E (A) | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) |
Sequence modifications
A: 1 - 333 (UniProt: Q86SQ9)
B: 73 - 293 (UniProt: Q96E22)
| PDB | External Database | Details |
|---|---|---|
| Gly -6 | - | expression tag |
| Ser -5 | - | expression tag |
| Gly -4 | - | expression tag |
| Ser -3 | - | expression tag |
| Gly -2 | - | expression tag |
| Ser -1 | - | expression tag |
| Gly 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Gly 72 | - | expression tag |
| - | Tyr 167 | deletion |
| - | Ser 168 | deletion |
| - | Pro 169 | deletion |
| - | Glu 170 | deletion |
| - | Phe 171 | deletion |
| - | Ala 172 | deletion |
| - | Asn 173 | deletion |
| - | Ser 174 | deletion |
| - | Asn 175 | deletion |
| Thr 249 | Ser 249 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 62995.2 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 668.8 | |
| All* | Total formula weight | 63664.0 |
