9QYK

Crystal structure of human L-lactate Dehydrogenase B protein in complex with NADH, oxamate and sertraline

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D (A, B, C, D)	L-lactate dehydrogenase B chain	polymer	348	38471.2	4	UniProt (P07195) Pfam (PF00056) Pfam (PF02866)	Homo sapiens (human)	LDH-B,LDH heart subunit,LDH-H,Renal carcinoma antigen NY-REN-46
2	E, I, K (A, B, C)	OXAMIC ACID	non-polymer		89.0	3	Chemie (OXM) PubChem (974)
3	F, J, L (A, B, C)	1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE	non-polymer		665.4	3	Chemie (NAI)
4	G, H, M (B, D)	(1S,4S)-4-(3,4-dichlorophenyl)-N-methyl-1,2,3,4-tetrahydronaphthalen-1-amine	non-polymer		306.2	3	Chemie (SRE) PubChem (68617)
5	N, O, P, Q (A, B, C, D)	water	water		18.0	868	Chemie (HOH)

Sequence modifications

A, B, C, D: 1 - 333 (UniProt: P07195)

PDB	External Database	Details
Glu 334	-	expression tag
Asn 335	-	expression tag
Leu 336	-	expression tag
Tyr 337	-	expression tag
Phe 338	-	expression tag
Gln 339	-	expression tag
Gly 340	-	expression tag
Leu 341	-	expression tag
Glu 342	-	expression tag
His 343	-	expression tag
His 344	-	expression tag
His 345	-	expression tag
His 346	-	expression tag
His 347	-	expression tag
His 348	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	153885.0
Non-Polymers*	Number of molecules	9
	Total formula weight	3182.2
All*	Total formula weight	157067.1

*Water molecules are not included.