9QX6
Crystal structure of RXR alpha LBD bound to a synthetic agonist FN537 and a coactivator fragment
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Retinoic acid receptor RXR-alpha | polymer | 235 | 26353.6 | 1 | UniProt (P19793) Pfam (PF00104) | Homo sapiens (human) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| 2 | B (B) | Nuclear receptor coactivator 2 | polymer | 10 | 1276.5 | 1 | UniProt (Q15596) | Homo sapiens | NCoA-2,Class E basic helix-loop-helix protein 75,bHLHe75,Transcriptional intermediary factor 2,hTIF2 |
| 3 | C (A) | (6R,6aR,7S,10R,10aS)-6-(3,5-bis(trifluoromethyl)phenyl)-5,6,6a,7,8,9,10,10a-octahydro-7,10-methanophenanthridine-3-carboxylic acid | non-polymer | 455.4 | 1 | Chemie (A1JAT) | |||
| 4 | D (A) | 6S,6aS,7R,10S,10aR)-6-(3,5-bis(trifluoromethyl)phenyl)-5,6,6a,7,8,9,10,10a-octahydro-7,10-methanophenanthridine-3-carboxylic acid | non-polymer | 455.4 | 1 | Chemie (A1JHO) | |||
| 5 | E, F (A, B) | water | water | 18.0 | 147 | Chemie (HOH) |
Sequence modifications
A: 229 - 462 (UniProt: P19793)
| PDB | External Database | Details |
|---|---|---|
| Ser 228 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 27630.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 910.8 | |
| All* | Total formula weight | 28540.9 |
