9QTO
Human alpha7 nicotinic receptor in complex with the E6 nanobody
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D, E (A, B, C, D, E) | Neuronal acetylcholine receptor subunit alpha-7,CHRNA7 (exons 5-10) and FAM7A (exons A-E) fusion | polymer | 375 | 42837.7 | 5 | UniProt (P36544) UniProt (A0A0A6YYA8) | Homo sapiens (human) | |
| 2 | F, G, H, I, J (F, G, H, I, J) | Nanobody E6 | polymer | 159 | 17089.7 | 5 | Vicugna pacos | ||
| 3 | K, N, Q, T, W (K, N, Q, T, W) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 5 | In PDB GlyTouCan (G22768VO) | |||
| 4 | L, O, R, U, X (L, O, R, U, X) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 570.5 | 5 | In PDB GlyTouCan (G21290RB) | |||
| 5 | M, P, S, V, Y (M, P, S, V, Y) | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 732.7 | 5 | In PDB GlyTouCan (G32152BH) | |||
| 6 | AA, BA, CA, DA, EA... (B, C, D, E, F...) | water | water | 18.0 | 292 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 326 (UniProt: P36544)
A, B, C, D, E: 328 - 375 (UniProt: A0A0A6YYA8)
| PDB | External Database | Details |
|---|---|---|
| Asp 325 | Pro 348 | conflict |
| Val 327 | - | linker |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 10 |
| Total formula weight | 299636.9 | |
| Branched | Number of molecules | 15 |
| Total formula weight | 11070.2 | |
| All* | Total formula weight | 310707.2 |
