9QS2
Crystal structure of Zika Virus NS2B-NS3 protease in complex with Z100582766
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine protease subunit NS2B | polymer | 53 | 5865.4 | 1 | UniProt (Q32ZE1) Pfam (PF01002) | Zika virus | Flavivirin protease NS2B regulatory subunit,Non-structural protein 2B |
| 2 | B (B) | Genome polyprotein | polymer | 176 | 18877.4 | 1 | UniProt (Q32ZE1) Pfam (PF00949) | Zika virus | |
| 3 | C (B) | 1-methyl-~{N}-(pyridin-2-ylmethyl)pyrazole-4-carboxamide | non-polymer | 216.2 | 1 | Chemie (A1I9X) PubChem (35294804) | |||
| 4 | D, E (A, B) | water | water | 18.0 | 88 | Chemie (HOH) |
Sequence modifications
A: 46 - 96 (UniProt: Q32ZE1)
B: 2 - 177 (UniProt: Q32ZE1)
| PDB | External Database | Details |
|---|---|---|
| Met 44 | - | initiating methionine |
| Thr 45 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Lys 107 | Arg 1605 | engineered mutation |
| Ser 143 | Cys 1641 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 24742.8 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 216.2 | |
| All* | Total formula weight | 24959.0 |
