9QRV

Crystal Structure of an anti-VWF CK Domain Fab in Complex with the C-Terminal CK Domain of Cynomolgus Monkey von Willebrand Factor.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (D)	von Willebrand factor	polymer	113	12566.2	1	UniProt (A0A2K5X4G5)	Macaca fascicularis (crab-eating macaque)	vWF
2	B (H)	VH-CH1	polymer	224	23775.6	1		synthetic construct
3	C (L)	Kappa light chain	polymer	213	23056.6	1		synthetic construct
4	D (A)	beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose	branched		586.5	1	In PDB GlyTouCan (G15407YE)
5	E, G, H, I, J... (D, H, L)	SULFATE ION	non-polymer		96.1	12	Chemie (SO4)
6	F (H)	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
7	R (L)	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
8	S, T, U (D, H, L)	water	water		18.0	63	Chemie (HOH)

Sequence modifications

D: 21 - 113 (UniProt: A0A2K5X4G5)

PDB	External Database	Details
Ala 1	-	expression tag
Glu 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
Gly 9	-	expression tag
Ser 10	-	expression tag
Ser 11	-	expression tag
Ala 12	-	expression tag
Leu 13	-	expression tag
Glu 14	-	expression tag
Val 15	-	expression tag
Leu 16	-	expression tag
Phe 17	-	expression tag
Gln 18	-	expression tag
Gly 19	-	expression tag
Pro 20	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	59398.4
Branched	Number of molecules	1
	Total formula weight	586.5
Non-Polymers*	Number of molecules	14
	Total formula weight	1267.8
All*	Total formula weight	61252.8

*Water molecules are not included.