9QRL

DNA polymerase with inhibitor #2

This is a non-PDB format compatible entry.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	DNA polymerase III PolC-type	polymer	1474	166595.8	1	UniProt (A0A9X4B319)	Enterococcus faecium	PolIII
2	B (E)	DNA (5'-D(P*TP*AP*A)-3')	polymer	3	885.6	1		Escherichia coli
3	C (P)	DNA (5'-D(P*GP*GP*TP*GP*CP*GP*CP*AP*T)-3')	polymer	33	10179.6	1		Escherichia coli
4	D (T)	DNA (5'-D(P*CP*CP*AP*TP*GP*CP*GP*CP*AP*CP*C)-3')	polymer	42	12724.1	1		Escherichia coli
5	E, F, G, H (A)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
6	I, J (A)	MAGNESIUM ION	non-polymer		24.3	2	Chemie (MG)
7	K (T)	Ibezapolstat	non-polymer		423.3	1	Chemie (A1I9T)
8	L (A)	water	water		18.0	1	Chemie (HOH)

Sequence modifications

A: 1 - 1452 (UniProt: A0A9X4B319)

PDB	External Database	Details
Met -21	-	initiating methionine
Gly -20	-	expression tag
Ser -19	-	expression tag
Ser -18	-	expression tag
His -17	-	expression tag
His -16	-	expression tag
His -15	-	expression tag
His -14	-	expression tag
His -13	-	expression tag
His -12	-	expression tag
Ser -11	-	expression tag
Ser -10	-	expression tag
Gly -9	-	expression tag
Leu -8	-	expression tag
Val -7	-	expression tag
Pro -6	-	expression tag
Arg -5	-	expression tag
Gly -4	-	expression tag
Ser -3	-	expression tag
His -2	-	expression tag
Met -1	-	expression tag
His 0	-	expression tag
Lys 22	Arg 22	conflict
His 218	-	insertion
Ile 219	-	insertion
Thr 355	Ile 353	conflict
Ala 431	Asp 429	engineered mutation
Ala 433	Glu 431	engineered mutation
Gly 484	Glu 482	conflict
Lys 857	Glu 855	conflict
Ser 1141	Thr 1139	conflict

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	190385.1
Non-Polymers*	Number of molecules	7
	Total formula weight	733.5
All*	Total formula weight	191118.7

*Water molecules are not included.