9QRK
Structure of BromoCatch: Brd2BD2 L383A,D434C in complex with MR116.
This is a non-PDB format compatible entry.
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Bromodomain-containing protein 2 | polymer | 113 | 13143.1 | 1 | UniProt (P25440) Pfam (PF00439) | Homo sapiens (human) | O27.1.1 |
| 2 | B (A) | methyl (2R)-2-[4,5,13-trimethyl-7-[4-(propanoylamino)phenyl]-3-thia-1,8,11,12-tetrazatricyclo[8.3.0.0^{2,6}]trideca-2(6),4,7,10,12-pentaen-9-yl]butanoate | non-polymer | 479.6 | 1 | Chemie (A1I9R) | |||
| 3 | C (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 4 | D (A) | water | water | 18.0 | 161 | Chemie (HOH) |
Sequence modifications
A: 348 - 455 (UniProt: P25440)
| PDB | External Database | Details |
|---|---|---|
| Ser 343 | - | expression tag |
| Gly 344 | - | expression tag |
| Ala 345 | - | expression tag |
| Asn 346 | - | expression tag |
| Pro 347 | - | expression tag |
| Ala 383 | Leu 383 | engineered mutation |
| Cys 434 | Asp 434 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 13143.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 541.7 | |
| All* | Total formula weight | 13684.7 |
