9QQZ

Cobalamin-binding chimera 2 (Cob02)

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Coenzyme B12-dependent mutase,Uroporphyrinogen-III synthase	polymer	286	31542.5	1	UniProt (Q9YBB1) UniProt (P10746)	Homo sapiens (human)	UROIIIS,UROS,Hydroxymethylbilane hydrolyase [cyclizing],Uroporphyrinogen-III cosynthase
2	B (A)	water	water		18.0	31	Chemie (HOH)

Sequence modifications

A: 2 - 36 (UniProt: Q9YBB1)

PDB	External Database	Details
Met 1	-	initiating methionine

A: 37 - 184 (UniProt: P10746)

PDB	External Database	Details
Ala 182	Gln 177	engineered mutation

A: 185 - 274 (UniProt: Q9YBB1)

PDB	External Database	Details
Ser 245	Gly 121	engineered mutation
Glu 275	-	expression tag
Ala 276	-	expression tag
Glu 277	-	expression tag
Ala 278	-	expression tag
Leu 279	-	expression tag
Glu 280	-	expression tag
His 281	-	expression tag
His 282	-	expression tag
His 283	-	expression tag
His 284	-	expression tag
His 285	-	expression tag
His 286	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	31542.5
All*	Total formula weight	31542.5

*Water molecules are not included.