9QQU

Crystal structure of an engineered TPR domain in complex with the HSP90 peptide MEEVD

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Stress-induced-phosphoprotein 1	polymer	151	17880.1	1	UniProt (P31948) Pfam (PF13181) Pfam (PF00515)	Homo sapiens (human)	STI1,Hsc70/Hsp90-organizing protein,Hop,Renal carcinoma antigen NY-REN-11,Transformation-sensitive protein IEF SSP 3521
2	B (B)	Heat shock protein HSP 90-alpha	polymer	6	647.7	1	UniProt (P07900)	Homo sapiens (human)	Heat shock 86 kDa,HSP 86,HSP86,Heat shock protein family C member 1,Lipopolysaccharide-associated protein 2,LAP-2,LPS-associated protein 2,Renal carcinoma antigen NY-REN-38
3	C, D (A, B)	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
4	E, F (A, B)	water	water		18.0	39	Chemie (HOH)

Sequence modifications

A: 19 - 151 (UniProt: P31948)

PDB	External Database	Details
Met 1	-	initiating methionine
His 2	-	expression tag
His 3	-	expression tag
His 4	-	expression tag
His 5	-	expression tag
His 6	-	expression tag
His 7	-	expression tag
Ser 8	-	expression tag
Ser 9	-	expression tag
Gly 10	-	expression tag
Thr 11	-	expression tag
Glu 12	-	expression tag
Asn 13	-	expression tag
Leu 14	-	expression tag
Tyr 15	-	expression tag
Phe 16	-	expression tag
Gln 17	-	expression tag
Ser 18	-	expression tag
Glu 27	Leu 226	engineered mutation
Arg 28	Lys 227	engineered mutation
Glu 47	Lys 246	engineered mutation
Ile 53	Lys 252	engineered mutation
Met 73	Lys 272	engineered mutation
Asp 77	Asn 276	engineered mutation
Ala 95	Glu 294	engineered mutation
Lys 98	Arg 297	engineered mutation
Ala 108	Gly 307	engineered mutation
Gly 115	Glu 314	engineered mutation
Lys 122	His 321	engineered mutation
Tyr 123	Phe 322	engineered mutation
Thr 129	Ala 328	engineered mutation
Lys 141	Gln 340	engineered mutation
Glu 142	Gln 341	engineered mutation

B: 2 - 6 (UniProt: P07900)

PDB	External Database	Details
Ace 1	-	acetylation

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	18527.8
Non-Polymers*	Number of molecules	2
	Total formula weight	192.1
All*	Total formula weight	18719.9

*Water molecules are not included.