9QO4
Dissociation-state-3 of 9-subunit CSN and SCF (SKP1-SKP2-CKS1) complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | COP9 signalosome complex subunit 1 | polymer | 491 | 55606.5 | 1 | UniProt (Q13098) | Homo sapiens (human) | Signalosome subunit 1,G protein pathway suppressor 1,GPS-1,JAB1-containing signalosome subunit 1,Protein MFH |
| 2 | B (B) | COP9 signalosome complex subunit 2 | polymer | 443 | 51664.6 | 1 | UniProt (P61201) | Homo sapiens (human) | Signalosome subunit 2,Alien homolog,JAB1-containing signalosome subunit 2,Thyroid receptor-interacting protein 15,TRIP-15 |
| 3 | C (C) | COP9 signalosome complex subunit 3 | polymer | 423 | 47924.0 | 1 | UniProt (Q9UNS2) | Homo sapiens (human) | SGN3,Signalosome subunit 3,JAB1-containing signalosome subunit 3 |
| 4 | D (D) | COP9 signalosome complex subunit 4 | polymer | 406 | 46322.7 | 1 | UniProt (Q9BT78) | Homo sapiens (human) | SGN4,Signalosome subunit 4,JAB1-containing signalosome subunit 4 |
| 5 | E (E) | COP9 signalosome complex subunit 5 | polymer | 334 | 37563.7 | 1 | UniProt (Q92905) | Homo sapiens (human) | SGN5,Signalosome subunit 5,Jun activation domain-binding protein 1 |
| 6 | F (F) | COP9 signalosome complex subunit 6 | polymer | 327 | 36203.4 | 1 | UniProt (Q7L5N1) | Homo sapiens (human) | Signalosome subunit 6,JAB1-containing signalosome subunit 6,MOV34 homolog,Vpr-interacting protein,hVIP |
| 7 | G (G) | COP9 signalosome complex subunit 7b | polymer | 264 | 29656.9 | 1 | UniProt (Q9H9Q2) | Homo sapiens (human) | SGN7b,Signalosome subunit 7b,JAB1-containing signalosome subunit 7b |
| 8 | H (H) | COP9 signalosome complex subunit 8 | polymer | 209 | 23245.5 | 1 | UniProt (Q99627) | Homo sapiens (human) | Signalosome subunit 8,COP9 homolog,hCOP9,JAB1-containing signalosome subunit 8 |
| 9 | I (I) | Cullin-1 | polymer | 776 | 89800.4 | 1 | UniProt (Q13616) | Homo sapiens (human) | CUL-1 |
| 10 | J (J) | E3 ubiquitin-protein ligase RBX1 | polymer | 108 | 12290.0 | 1 | UniProt (P62877) | Homo sapiens (human) | E3 ubiquitin-protein transferase RBX1,Protein ZYP,RING finger protein 75,RING-box protein 1,Rbx1,Regulator of cullins 1,ROC1 |
| 11 | K (L) | S-phase kinase-associated protein 1 | polymer | 163 | 18680.0 | 1 | UniProt (P63208) | Homo sapiens (human) | Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1 |
| 12 | L (M) | S-phase kinase-associated protein 2 | polymer | 424 | 47817.8 | 1 | UniProt (Q13309) | Homo sapiens (human) | Cyclin-A/CDK2-associated protein p45,F-box protein Skp2,F-box/LRR-repeat protein 1,p45skp2 |
| 13 | M (N) | Cyclin-dependent kinases regulatory subunit 1 | polymer | 79 | 9679.2 | 1 | UniProt (P61024) | Homo sapiens (human) | CKS-1 |
| 14 | N (P) | COP9 signalosome complex subunit 9 | polymer | 57 | 6213.7 | 1 | UniProt (Q8WXC6) | Homo sapiens (human) | CSN acidic protein,CSNAP,Myeloma-overexpressed gene 2 protein |
| 15 | O (B) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) | |||
| 16 | P, Q, R, S (E, J) | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
| 17 | T (E) | water | water | 18.0 | 1 | Chemie (HOH) |
Sequence modifications
E: 1 - 334 (UniProt: Q92905)
| PDB | External Database | Details |
|---|---|---|
| Ala 104 | Glu 104 | conflict |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 14 |
| Total formula weight | 512668.3 | |
| Non-Polymers* | Number of molecules | 5 |
| Total formula weight | 921.7 | |
| All* | Total formula weight | 513590.0 |
