9QO0
Pre-activated 9-subunit COP9 signalosome and neddylated SCF (Skp1-Skp2-Cks1) complex structure
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (D) | COP9 signalosome complex subunit 4 | polymer | 406 | 46322.7 | 1 | UniProt (Q9BT78) Pfam (PF01399) Pfam (PF18420) Pfam (PF22241) | Homo sapiens (human) | SGN4,Signalosome subunit 4,JAB1-containing signalosome subunit 4 |
| 2 | B (G) | COP9 signalosome complex subunit 7b | polymer | 264 | 29656.9 | 1 | UniProt (Q9H9Q2) Pfam (PF22061) Pfam (PF01399) Pfam (PF18392) | Homo sapiens (human) | SGN7b,Signalosome subunit 7b,JAB1-containing signalosome subunit 7b |
| 3 | C (K) | NEDD8 | polymer | 76 | 8574.0 | 1 | UniProt (Q15843) Pfam (PF00240) | Homo sapiens (human) | Neddylin,Neural precursor cell expressed developmentally down-regulated protein 8,NEDD-8,Ubiquitin-like protein Nedd8 |
| 4 | D (N) | Cyclin-dependent kinases regulatory subunit 1 | polymer | 79 | 9679.2 | 1 | UniProt (P61024) Pfam (PF01111) | Homo sapiens (human) | CKS-1 |
| 5 | E (P) | COP9 signalosome complex subunit 9 | polymer | 57 | 6213.7 | 1 | UniProt (Q8WXC6) Pfam (PF15004) | Homo sapiens (human) | CSN acidic protein,CSNAP,Myeloma-overexpressed gene 2 protein |
| 6 | F (A) | COP9 signalosome complex subunit 1 | polymer | 491 | 55606.5 | 1 | UniProt (Q13098) Pfam (PF10602) Pfam (PF01399) Pfam (PF21151) | Homo sapiens (human) | Signalosome subunit 1,G protein pathway suppressor 1,GPS-1,JAB1-containing signalosome subunit 1,Protein MFH |
| 7 | G (B) | COP9 signalosome complex subunit 2 | polymer | 443 | 51664.6 | 1 | UniProt (P61201) Pfam (PF01399) Pfam (PF25983) | Homo sapiens (human) | Signalosome subunit 2,Alien homolog,JAB1-containing signalosome subunit 2,Thyroid receptor-interacting protein 15,TRIP-15 |
| 8 | H (C) | COP9 signalosome complex subunit 3 | polymer | 423 | 47924.0 | 1 | UniProt (Q9UNS2) Pfam (PF22788) Pfam (PF01399) Pfam (PF21215) | Homo sapiens (human) | SGN3,Signalosome subunit 3,JAB1-containing signalosome subunit 3 |
| 9 | I (E) | COP9 signalosome complex subunit 5 | polymer | 334 | 37621.7 | 1 | UniProt (Q92905) Pfam (PF01398) Pfam (PF18323) | Homo sapiens (human) | SGN5,Signalosome subunit 5,Jun activation domain-binding protein 1 |
| 10 | J (F) | COP9 signalosome complex subunit 6 | polymer | 327 | 36203.4 | 1 | UniProt (Q7L5N1) Pfam (PF01398) Pfam (PF13012) | Homo sapiens (human) | Signalosome subunit 6,JAB1-containing signalosome subunit 6,MOV34 homolog,Vpr-interacting protein,hVIP |
| 11 | K (H) | COP9 signalosome complex subunit 8 | polymer | 209 | 23245.5 | 1 | UniProt (Q99627) Pfam (PF10075) | Homo sapiens (human) | Signalosome subunit 8,COP9 homolog,hCOP9,JAB1-containing signalosome subunit 8 |
| 12 | L (I) | Cullin-1 | polymer | 776 | 89800.4 | 1 | UniProt (Q13616) Pfam (PF00888) Pfam (PF26557) Pfam (PF10557) | Homo sapiens (human) | CUL-1 |
| 13 | M (J) | E3 ubiquitin-protein ligase RBX1 | polymer | 108 | 12290.0 | 1 | UniProt (P62877) Pfam (PF12678) | Homo sapiens (human) | E3 ubiquitin-protein transferase RBX1,Protein ZYP,RING finger protein 75,RING-box protein 1,Rbx1,Regulator of cullins 1,ROC1 |
| 14 | N (L) | S-phase kinase-associated protein 1 | polymer | 163 | 18680.0 | 1 | UniProt (P63208) Pfam (PF03931) Pfam (PF01466) | Homo sapiens (human) | Cyclin-A/CDK2-associated protein p19,p19A,Organ of Corti protein 2,OCP-2,Organ of Corti protein II,OCP-II,RNA polymerase II elongation factor-like protein,SIII,Transcription elongation factor B polypeptide 1-like,p19skp1 |
| 15 | O (M) | S-phase kinase-associated protein 2 | polymer | 424 | 47817.8 | 1 | UniProt (Q13309) Pfam (PF12937) | Homo sapiens (human) | Cyclin-A/CDK2-associated protein p45,F-box protein Skp2,F-box/LRR-repeat protein 1,p45skp2 |
| 16 | P (B) | INOSITOL HEXAKISPHOSPHATE | non-polymer | 660.0 | 1 | Chemie (IHP) | |||
| 17 | Q, R, S (J) | ZINC ION | non-polymer | 65.4 | 3 | Chemie (ZN) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 15 |
| Total formula weight | 521300.3 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 856.3 | |
| All* | Total formula weight | 522156.6 |
