9QK0
GABA-A receptor a2b3g2 + a2NB25(inhibitor)
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, D (A, D) | Gamma-aminobutyric acid receptor subunit alpha-2 | polymer | 354 | 40452.4 | 2 | UniProt (P47869) | Homo sapiens (human) | GABA(A) receptor subunit alpha-2,GABAAR subunit alpha-2 |
| 2 | B, E (B, E) | Gamma-aminobutyric acid receptor subunit beta-3,Soluble cytochrome b562 | polymer | 451 | 51615.1 | 2 | UniProt (P28472) UniProt (P0ABE7) | Homo sapiens (human) | GABA(A) receptor subunit beta-3,GABAAR subunit beta-3,Cytochrome b-562 |
| 3 | C (C) | Gamma-aminobutyric acid receptor subunit gamma-2 | polymer | 371 | 42798.9 | 1 | UniProt (P18507) | Homo sapiens (human) | GABA(A) receptor subunit gamma-2,GABAAR subunit gamma-2 |
| 4 | F, G (F, G) | a2VHH25 | polymer | 136 | 14981.5 | 2 | Lama glama | ||
| 5 | H (H) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1235.1 | 1 | In PDB GlyTouCan (G55220VL) | |||
| 6 | I, L (J, O) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 7 | J, M (K, P) | alpha-D-mannopyranose-(1-3)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1073.0 | 2 | In PDB GlyTouCan (G09724ZC) | |||
| 8 | K (M) | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 1 | In PDB GlyTouCan (G22768VO) | |||
| 9 | N, O, P (A, C, D) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 3 | Chemie (NAG) PubChem (24139) |
Sequence modifications
A, D: 1 - 311 (UniProt: P47869)
A, D: 388 - 423 (UniProt: P47869)
B, E: 1 - 307 (UniProt: P28472)
B, E: 308 - 312 (UniProt: P0ABE7)
B, E: 422 - 448 (UniProt: P28472)
C: 1 - 322 (UniProt: P18507)
C: 409 - 436 (UniProt: P18507)
A, D: 388 - 423 (UniProt: P47869)
| PDB | External Database | Details |
|---|---|---|
| Ser 312 | - | linker |
| Gln 313 | - | linker |
| Pro 314 | - | linker |
| Ala 315 | - | linker |
| Arg 316 | - | linker |
| Ala 317 | - | linker |
| Ala 318 | - | linker |
B, E: 308 - 312 (UniProt: P0ABE7)
| PDB | External Database | Details |
|---|---|---|
| Trp 308 | Met 29 | conflict |
| Ile 312 | His 124 | conflict |
| Leu 312 | - | linker |
| Thr 312 | - | linker |
| Gly 312 | - | linker |
| Arg 419 | - | linker |
| Ala 420 | - | linker |
| Ala 421 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ser 308 | - | linker |
| Gln 308 | - | linker |
| Pro 308 | - | linker |
| Ala 308 | - | linker |
| Gly 308 | - | linker |
| Thr 308 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Thr 11 | Ala 50 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Ser 323 | - | linker |
| Gln 324 | - | linker |
| Pro 325 | - | linker |
| Ala 326 | - | linker |
| Arg 327 | - | linker |
| Ala 328 | - | linker |
| Ala 329 | - | linker |
| Gly 437 | - | expression tag |
| Thr 438 | - | expression tag |
| Gly 439 | - | expression tag |
| Thr 440 | - | expression tag |
| Gly 441 | - | expression tag |
| Thr 442 | - | expression tag |
| Glu 443 | - | expression tag |
| Thr 444 | - | expression tag |
| Ser 445 | - | expression tag |
| Gln 446 | - | expression tag |
| Val 447 | - | expression tag |
| Ala 448 | - | expression tag |
| Pro 449 | - | expression tag |
| Ala 450 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 7 |
| Total formula weight | 256896.9 | |
| Branched | Number of molecules | 6 |
| Total formula weight | 5140.7 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 663.6 | |
| All* | Total formula weight | 262701.2 |
